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However, quantitative data are scarce, prompting the need for our investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>A comprehensive systematic review was performed from inception to November 16, 2022, with the restriction of English language, not including review articles. Article screening and extraction was performed independently, and shortlisted articles were assessed for bias. Analysis was performed using SPSS Version 25 (IBM\u00ae SPSS\u00ae Statistics; Chicago, IL, USA). Data were presented as frequencies and percentages, with a confidence interval of 95%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>This review included 134 patients, with 78 (58.2%) males. Mean age was 53.6\u2009years and included two pediatric patients. The most common comorbidity was diabetes (9.7%). Prevalent presenting symptoms included pain (47.8%) and swelling (35.1%). A mean of 2.51 organs or anatomical sites was affected, retroperitoneum (64.2%) being most affected. The pancreas (30.0%) and digestive system (47.0%) were the organs\/organ systems most affected. Patients had favorable outcomes in 79.1% of cases, 87.3% had no relapse, and 91.8% of patients survived the condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings in this study provide a quantitative measurement of the demographics, presentations, organ manifestations, and outcomes of multifocal fibrosclerosis. We found the disease to be prevalent in males in Japan or the United States, with the abdomen and its organs being commonly involved.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121231178046","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T02:27:25Z","timestamp":1685413645000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical presentation and organ-based outcomes of Multifocal fibrosclerosis: A systematic review"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3591-3614","authenticated-orcid":false,"given":"Ahmed Safi","family":"Vahidy","sequence":"first","affiliation":[{"name":"Department of Medicine, Dow University of Health Sciences, Karachi, SD, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-6148","authenticated-orcid":false,"given":"Sameer Saleem","family":"Tebha","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Neurology, Jinnah Medical and Dental College, Karachi, SD, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeny","family":"Chavarria","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4292-6146","authenticated-orcid":false,"given":"Sandip","family":"KC","sequence":"additional","affiliation":[{"name":"Department of Medicine, HAMS Hospital, Kathmandu, BA, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1809-0196","authenticated-orcid":false,"given":"Shristi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Medicine, HAMS Hospital, Kathmandu, BA, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"bibr1-20503121231178046","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.2424"},{"key":"bibr2-20503121231178046","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-66-5-884"},{"key":"bibr3-20503121231178046","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1601"},{"key":"bibr4-20503121231178046","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-1604-7.00284-0"},{"key":"bibr5-20503121231178046","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441005"},{"key":"bibr6-20503121231178046","doi-asserted-by":"publisher","DOI":"10.1080\/00313020902756394"},{"key":"bibr7-20503121231178046","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002766"},{"key":"bibr8-20503121231178046","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.205526"},{"key":"bibr9-20503121231178046","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00056-9"},{"key":"bibr10-20503121231178046","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216561"},{"key":"bibr11-20503121231178046","first-page":"19","volume":"401","author":"Kamisawa T","year":"2017","journal-title":"Curr Top Microbiol Immunol"},{"key":"bibr12-20503121231178046","doi-asserted-by":"publisher","DOI":"10.1002\/art.34593"},{"key":"bibr13-20503121231178046","first-page":"1052","volume":"40","author":"Scriffignano S","year":"2022","journal-title":"Clin Exp Rheumatol"},{"key":"bibr14-20503121231178046","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15867"},{"key":"bibr15-20503121231178046","doi-asserted-by":"crossref","unstructured":"Vahidy A, Tebha S, Chavarria Y, et al. 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