{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:25:23Z","timestamp":1787894723525,"version":"build-2784847793"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Obstructive sleep apnea syndrome is associated with cardiovascular diseases. Mean platelet volume has emerged as a marker of prothrombotic conditions and cardiovascular risk. The aim of this study was to investigate the association between the mean platelet volume and cardiovascular diseases in patients with obstructive sleep apnea syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The medical records of 207 patients were analyzed. Obstructive sleep apnea syndrome was diagnosed by polygraphy, and patients were classified according to apnea\u2013hypopnea index: control group: individuals with simple snoring (apnea\u2013hypopnea index\u2009&lt;\u20095), mild obstructive sleep apnea syndrome group (5\u2009\u2a7d\u2009apnea\u2013hypopnea index\u2009&lt;\u200915), moderate obstructive sleep apnea syndrome group (15\u2009\u2a7d\u2009apnea\u2013hypopnea index\u2009&lt;\u200930), and severe obstructive sleep apnea syndrome group (apnea\u2013hypopnea index\u2009\u2a7e\u200930). Mean platelet volume was obtained from medical records. Cardiovascular diseases were defined if patients had hypertension, heart failure, coronary artery disease, or arrythmia. The independent predictors related to cardiovascular diseases in obstructive sleep apnea syndrome were determined by using multiple logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the patients, 175 were included in the analysis. Sixty-three (36%) were males and 112 (64%) were females. The mean age was 51.85\u2009\u00b1\u200911\u2009years. There were, 26 (14.9%), 53 (30.3%), 38 (21.7%), and 58 (33.1%) participants in the simple snoring, mild, moderate, and severe obstructive sleep apnea syndrome groups, respectively. Cardiovascular diseases were significantly different between the four groups ( p\u2009=\u20090.014). Mean platelet volume in severe obstructive sleep apnea syndrome group was significantly higher than in mild or moderate obstructive sleep apnea syndrome group and simple snoring group ( p\u2009&lt;\u20090.05). Moreover, there was a positive correlation between mean platelet volume levels and apnea\u2013hypopnea index ( r\u2009=\u20090.424; p\u2009&lt;\u20090.001). The independent predictors of cardiovascular diseases in obstructive sleep apnea syndrome were age ( p\u2009&lt;\u20090.001; odds ratio\u2009=\u20091.134; confidence interval: 1.072\u20131.2), body mass index ( p\u2009=\u20090.012; odds ratio: 1.105; confidence interval: 1.022\u20131.194), and mean platelet volume ( p\u2009&lt;\u20090.001; odds ratio: 2.092; confidence interval: 1.386\u20133.158).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The present study demonstrated that there is an association between mean platelet volume levels and cardiovascular diseases in patients with obstructive sleep apnea syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121231181634","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T03:05:40Z","timestamp":1687575940000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between mean platelet volume and cardiovascular disease in obstructive sleep apnea syndrome"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-8237","authenticated-orcid":false,"given":"Souha","family":"Kallel","sequence":"first","affiliation":[{"name":"Department of ENT and Cervicofacial Surgery. Habib Bourguiba\u2019s Teaching Hospital, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khouloud","family":"Kchaou","sequence":"additional","affiliation":[{"name":"Department of ENT and Cervicofacial Surgery. Habib Bourguiba\u2019s Teaching Hospital, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Kharrat","sequence":"additional","affiliation":[{"name":"Department of ENT and Cervicofacial Surgery. Habib Bourguiba\u2019s Teaching Hospital, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0880-1032","authenticated-orcid":false,"given":"Mohamed Amin","family":"Chaabouni","sequence":"additional","affiliation":[{"name":"Department of ENT and Cervicofacial Surgery. Habib Bourguiba\u2019s Teaching Hospital, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirine","family":"Ayedi","sequence":"additional","affiliation":[{"name":"Department of ENT and Cervicofacial Surgery. Habib Bourguiba\u2019s Teaching Hospital, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhem","family":"Charfeddine","sequence":"additional","affiliation":[{"name":"Department of ENT and Cervicofacial Surgery. Habib Bourguiba\u2019s Teaching Hospital, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,22]]},"reference":[{"key":"bibr1-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.3.2005065"},{"key":"bibr2-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.5.1442"},{"key":"bibr3-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws342"},{"key":"bibr4-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00111208"},{"key":"bibr5-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2012.02212.x"},{"key":"bibr6-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633695"},{"key":"bibr7-20503121231181634","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795049804"},{"key":"bibr8-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813726-0.00137-9"},{"key":"bibr9-20503121231181634","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"bibr10-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0970"},{"key":"bibr11-20503121231181634","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0810"},{"key":"bibr12-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"bibr13-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2009.01.002"},{"key":"bibr14-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1159\/000089814"},{"key":"bibr15-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0158"},{"key":"bibr16-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.1.188"},{"key":"bibr17-20503121231181634","doi-asserted-by":"publisher","DOI":"10.5606\/kbbihtisas.2015.28863"},{"key":"bibr18-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052627.99976.18"},{"key":"bibr19-20503121231181634","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2015(07)04"},{"key":"bibr20-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(83)90255-4"},{"key":"bibr21-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-017-1486-5"},{"key":"bibr22-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12823"},{"key":"bibr23-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcdt.2013.10.006"},{"issue":"1","key":"bibr24-20503121231181634","first-page":"29","volume":"4","author":"Meurice JC.","year":"2012","journal-title":"Rev Mal Respir Actual"},{"key":"bibr25-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32835e98da"},{"key":"bibr26-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9681595"},{"issue":"25","key":"bibr27-20503121231181634","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1161\/CIRCULATIONAHA.106.683482","volume":"115","author":"Arzt M","year":"2007","journal-title":"Circulation"},{"key":"bibr28-20503121231181634","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.520733"},{"key":"bibr29-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1177\/1076029612436675"},{"key":"bibr30-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051001"},{"key":"bibr31-20503121231181634","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90974-3"}],"container-title":["SAGE Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121231181634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20503121231181634","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121231181634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:25:54Z","timestamp":1777595154000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20503121231181634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":31,"alternative-id":["10.1177\/20503121231181634"],"URL":"https:\/\/doi.org\/10.1177\/20503121231181634","relation":{},"ISSN":["2050-3121","2050-3121"],"issn-type":[{"value":"2050-3121","type":"print"},{"value":"2050-3121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"20503121231181634"}}