{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:48:14Z","timestamp":1777880894676,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study intends to determine the association of parathormone with vitamin D and other biochemical parameters (calcium and phosphate) and evaluate the relationship between low vitamin D and parathormone levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A hospital-based cross-sectional study was conducted among 310 study participants over the period of 1\u2009year. Patients who underwent laboratory investigations for vitamin D, parathormone, calcium, and phosphate in the Clinical Biochemistry Laboratory at the Institute of Medicine, Tribhuvan University Teaching Hospital were included. Serum intact parathyroid hormone, vitamin D, calcium, and phosphate were measured in Abbott Architect (ci4100) integrated system autoanalyzer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among the 310 study participants, 177 (57%) were males and 43% were females. The mean age of the patient was 47.09\u2009\u00b1\u200919.01\u2009years. High intact parathyroid hormone (&gt;68\u2009pg\/ml) was observed in 73% of the patients. Low vitamin D (&lt;20\u2009ng\/ml) was present in 30.2% of the patients. The findings from our study depict that there is a negative significant correlation between intact parathyroid hormone levels, vitamin D, and calcium levels and a positive correlation between intact parathyroid hormone and phosphate levels ( p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The findings from our study illustrate that there is a swapping drift in the profile of hyperparathyroidism in the Nepalese population. We report the presence of hyperparathyroidism in the middle age group than in the older age group contradictory to that reported in the literature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121231182204","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T08:00:45Z","timestamp":1686988845000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biochemical spectrum of parathyroid hormone disorders in patients attending Tribhuvan University Teaching Hospital, Kathmandu, Nepal"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2866-7969","authenticated-orcid":false,"given":"Apeksha","family":"Niraula","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-7459","authenticated-orcid":false,"given":"Sujata","family":"Baidya","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eans Tara","family":"Tuladhar","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju Kumar","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aseem","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithileshwer","family":"Raut","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naresh","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Endocrinology, Maharajgunj Medical Campus, Institute of Medicine, TUTH, Kathmandu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,17]]},"reference":[{"key":"bibr1-20503121231182204","doi-asserted-by":"publisher","DOI":"10.4158\/EP161206.OR"},{"key":"bibr2-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0107"},{"key":"bibr3-20503121231182204","first-page":"40","volume":"57","author":"Harinarayan CV","year":"2009","journal-title":"J Assoc Physicians India"},{"key":"bibr4-20503121231182204","doi-asserted-by":"publisher","DOI":"10.3390\/nu5010111"},{"key":"bibr5-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050030"},{"key":"bibr6-20503121231182204","first-page":"1517","volume":"166","author":"Rucker D","year":"2002","journal-title":"Can Med Assoc J"},{"key":"bibr7-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X41435"},{"key":"bibr8-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12429"},{"key":"bibr9-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"bibr10-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78933-9"},{"key":"bibr11-20503121231182204","first-page":"207","volume":"48","author":"Masud F","year":"2007","journal-title":"Singapore Med J"},{"key":"bibr12-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.062877"},{"key":"bibr13-20503121231182204","first-page":"14","volume":"6","author":"Pourhoseingholi MA","year":"2013","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"bibr14-20503121231182204","first-page":"243","volume":"70","author":"Khan NB","year":"2020","journal-title":"JPMA"},{"key":"bibr15-20503121231182204","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.190560"},{"key":"bibr16-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfz021"},{"key":"bibr17-20503121231182204","doi-asserted-by":"publisher","DOI":"10.3390\/nu10121890"},{"issue":"3","key":"bibr18-20503121231182204","first-page":"171","volume":"30","author":"Kakava K","year":"2016","journal-title":"In Vivo"},{"key":"bibr19-20503121231182204","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.4.541"},{"key":"bibr20-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.02.001"},{"key":"bibr21-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-003-6903-1"},{"key":"bibr22-20503121231182204","unstructured":"Schafer AL and Hypocalcemia SDM. Diagnosis and treatment. MDText.com, Inc. 2016, https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279022\/"},{"key":"bibr23-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39582.589433.BE"},{"key":"bibr24-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-11888-1"},{"issue":"218","key":"bibr25-20503121231182204","first-page":"226","volume":"57","author":"Rai CK","year":"2019","journal-title":"JNMA J Nepal Med Assoc"},{"key":"bibr26-20503121231182204","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2017.70887"},{"key":"bibr27-20503121231182204","unstructured":"Hypervitaminosis D: Causes, symptoms, diagnosis, and treatment [Internet]. 2017 Available from: https:\/\/www.medicalnewstoday.com\/articles\/318415"},{"key":"bibr28-20503121231182204","doi-asserted-by":"publisher","DOI":"10.3329\/bjm.v33i2.59287"},{"key":"bibr29-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21177-4"},{"key":"bibr30-20503121231182204","doi-asserted-by":"publisher","DOI":"10.4103\/ijem.IJEM_322_19"},{"key":"bibr31-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2364"},{"key":"bibr32-20503121231182204","doi-asserted-by":"publisher","DOI":"10.3126\/mjsbh.v16i1.17266"},{"key":"bibr33-20503121231182204","doi-asserted-by":"publisher","DOI":"10.3126\/jaim.v9i2.32813"},{"key":"bibr34-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2010.12.003"},{"key":"bibr35-20503121231182204","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-010-9897-2"}],"container-title":["SAGE Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121231182204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20503121231182204","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121231182204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:25:56Z","timestamp":1777595156000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20503121231182204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":35,"alternative-id":["10.1177\/20503121231182204"],"URL":"https:\/\/doi.org\/10.1177\/20503121231182204","relation":{},"ISSN":["2050-3121","2050-3121"],"issn-type":[{"value":"2050-3121","type":"print"},{"value":"2050-3121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"20503121231182204"}}