{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:48:21Z","timestamp":1777880901317,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The study describes the clinical and laboratory profile of the patients with polycythemia vera at Komfo Anokye Teaching Hospital in Kumasi, Ghana.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and design:<\/jats:title>\n                    <jats:p>This was a retrospective hospital-based cohort study conducted from September 2020 to August 2022. Hematology clinic entry book was used to identify the patient\u2019s unique hospital code. Using these unique codes, retrospective data were collected using an Excel spreadsheet from the Hospital Lightwave health information management system (LHIMS) database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 20 participants were recruited over the period of 2\u2009years. The overall mean age was 51.53\u2009\u00b1\u200916.39\u2009years. The hematological profile of the male participants revealed a mean hemoglobin of 18.25\u2009\u00b1\u20091.373\u2009g\/dl, mean hematocrit of 52\u2009\u00b1\u20093.47%, and a mean platelet of 345.5\u2009\u00b1\u2009180.82. Comparatively, the mean hemoglobin, hematocrit, and platelet for the female participants were higher with figures of 19.26\u2009\u00b1\u20091.43\u2009g\/dl, 53\u2009\u00b1\u20093.61%, and 816\u2009\u00b1\u2009935.32, respectively. Headache, tiredness, numbness, splenomegaly, and abnormal labs were the most common reasons why participants sought medical attention. Majority (60%) of the study participants had Janus Kinase 2 mutation. New-onset hypertension was identified in 45% of the study participants during follow-up. Thromboembolism was seen in 10% of the study population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Polycythemia vera is an uncommon disease in Ghana mostly found in older males above 50\u2009years. It is important to recognize it early to initiate therapy aimed at preventing common complications such as hypertension and thromboembolism. Polycythemia vera should be considered a differential diagnosis for patients with secondary hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121231187747","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T05:26:18Z","timestamp":1690349178000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polycythemia vera disease profile in an African population\u2014experience from a tertiary facility in Ghana"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-9733","authenticated-orcid":false,"given":"Solomon","family":"Gyabaah","sequence":"first","affiliation":[{"name":"Komfo Anokye Teaching Hospital, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice Agyemang","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Komfo Anokye Teaching Hospital, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adwoa Agyemang","family":"Adu-Gyamfi","sequence":"additional","affiliation":[{"name":"Komfo Anokye Teaching Hospital, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick Nkrumah","family":"Gyabaah","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afia Serwaa","family":"Bonsu","sequence":"additional","affiliation":[{"name":"Komfo Anokye Teaching Hospital, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameyaw Prince","family":"Addo","sequence":"additional","affiliation":[{"name":"Bridgeport Hospital\/Yale New Haven Health, Bridgeport, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ohene Kwaku","family":"Opare Sem","sequence":"additional","affiliation":[{"name":"Komfo Anokye Teaching Hospital, Kumasi, Ghana"},{"name":"School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"bibr1-20503121231187747","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165805"},{"key":"bibr2-20503121231187747","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0207-9"},{"key":"bibr3-20503121231187747","unstructured":"Pillai AA, Fazal S, Babiker HM. 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