{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:13:35Z","timestamp":1790194415210,"version":"4.1.0"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The present research evaluated and compared effectiveness between nitrofurantoin and double antibiotic paste in alleviating post-operative pain in patients suffering from symptomatic irreversible pulpitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>There were 60 subjects enrolled who were allotted among three groups: Group 1 \u2013 Nitrofurantoin, Group 2 \u2013 double antibiotic paste, and Group 3 \u2013 Control. Succeeding access opening and chemo mechanical preparation, intracanal medicament was placed in the root canals. Using a numerical pain scale, pain scores were measured at the following time intervals: preoperative, 12, 24, 48, and 72\u2009h. One-way ANOVA and post hoc statistical analysis were conducted, with a p-value of\u2009\u2a7d\u2009considered as statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Preoperatively, most patients experienced moderate to severe pain. The patients in groups 1 and 2 reported considerable reduction in their pain scores ( p\u2009\u2a7d\u20090.001) on each time interval. However, patients in group 3 experienced a higher level of pain even at 72\u2009h. No considerable distinction was found among participant\u2019s pain scores of groups 1 and 2 ( p\u2009=\u20090.193).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>For effective pain-relieving, both nitrofurantoin and double antibiotic paste can be successfully used in patients suffering from symptomatic irreversible pulpitis. However, when calcium hydroxide was used, patients experience high levels of pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121231220794","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T00:00:19Z","timestamp":1703894419000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The effectiveness of single antibiotic paste nitrofurantoin V\/S double antibiotic paste in alleviation of post-operative pain of patients suffering from symptomatic irreversible pulpitis\u2014A randomized controlled trial"],"prefix":"10.1177","volume":"12","author":[{"given":"Hira","family":"Abbasi","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, Altamash Institute of Dental Medicine, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Saqib","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, Altamash Institute of Dental Medicine, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsheen","family":"Maqsood","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Bahria University Dental College, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan","family":"Jouhar","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, College of Dentistry, King Faisal University, Al-Ahsa, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Ziauddin College of Dentistry, ZiauddinUniversity, Karachi, 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