{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:49:16Z","timestamp":1777880956352,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002014"],"award-info":[{"award-number":["UL1 TR002014"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Heparin-induced thrombocytopenia can occur in obese subjects. The medical comorbidities associated with obesity may contribute to the pathogenesis of this disease. It is unknown, however, which specific medical comorbidities and if higher odds of thrombosis are present in obese heparin-induced thrombocytopenia patients. We sought to determine whether obese heparin-induced thrombocytopenia subjects had higher odds of both comorbidities and thrombosis, hypothesizing that this patient population would have higher odds of both these conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This was a multi-center retrospective study utilizing TriNetX\n                      <jats:sup>\u00a9<\/jats:sup>\n                      , an electronic health record database, in subjects aged 18\u201399\u2009years diagnosed with heparin-induced thrombocytopenia. The cohort was divided into two groups (1) non-obese (body mass index\u2009&lt;\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and (2) obese (body mass index\u2009\u2a7e\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). We evaluated patient characteristics, diagnostic, laboratory, medication, and procedure codes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 1583 subjects (696 (44.0%) non-obese and 887 (56.0%) obese) were included. Obese subjects had higher odds of diabetes with complications (OR\u2009=\u20091.73, 95% CI\u2009=\u20091.35\u20132.22, p\u2009&lt;\u20090.001) and without complications (OR\u2009=\u20091.81, 95% CI\u2009=\u20091.47\u20132.22, p\u2009&lt;\u20090.001). This association was still present after correcting for demographic and clinical factors. There were no increased odds of thrombosis observed in the obesity group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study found that obese heparin-induced thrombocytopenia subjects had higher odds of having a diabetes mellitus comorbidity, but did not have higher odds of thrombosis. Given obesity is considered a hypercoagulable state, further study may be needed to understand why obese subjects diagnosed with heparin-induced thrombocytopenia do not have higher rates of thrombosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121241247471","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T03:27:20Z","timestamp":1714966040000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of medical comorbidities in obese subjects diagnosed with heparin-induced thrombocytopenia"],"prefix":"10.1177","volume":"12","author":[{"given":"Matthew","family":"Darok","sequence":"first","affiliation":[{"name":"Pediatrics, Department of Pediatrics, Penn State Hershey Children\u2019s Hospital, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Daly","sequence":"additional","affiliation":[{"name":"Hospital Pediatrics, Department of Pediatrics, Penn State Hershey Children\u2019s Hospital, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vonn","family":"Walter","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-2568","authenticated-orcid":false,"given":"Conrad","family":"Krawiec","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care Medicine, Department of Pediatrics, Penn State Hershey Children\u2019s Hospital, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"bibr1-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-11-709873"},{"key":"bibr2-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1546"},{"key":"bibr3-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.03.026"},{"key":"bibr4-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2109"},{"key":"bibr5-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.11.039"},{"key":"bibr6-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-3-14"},{"key":"bibr7-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01787.x"},{"key":"bibr8-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000729"},{"key":"bibr9-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-661215"},{"key":"bibr10-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24006"},{"key":"bibr11-20503121241247471","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22040617"},{"key":"bibr12-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-427708"},{"key":"bibr13-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5446"},{"key":"bibr14-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/289645"},{"key":"bibr15-20503121241247471","doi-asserted-by":"publisher","DOI":"10.14740\/jh876"},{"key":"bibr16-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000952"},{"key":"bibr17-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2019.07.039"},{"key":"bibr18-20503121241247471","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7080203"},{"key":"bibr19-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.193"},{"key":"bibr20-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-013-3316-9"},{"key":"bibr21-20503121241247471","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.94.9.1587"},{"key":"bibr22-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"bibr23-20503121241247471","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04071206"},{"key":"bibr24-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002963"},{"key":"bibr25-20503121241247471","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty315"},{"key":"bibr26-20503121241247471","unstructured":"Aragon TJ, Fay MP, Wollschlaeger D, et al. epitools: epidemiology tools, https:\/\/CRAN.R-project.org\/package=epitools (2020, accessed 28 January 2022)."},{"key":"bibr27-20503121241247471","unstructured":"Vanegas LH, Rond\u00f3n LM, Paula GA. glmtoolbox: set of tools to data analysis using generalized linear models, https:\/\/cran.r-project.org\/web\/packages\/glmtoolbox\/index.html (2023, accessed 31 October 2023)."},{"key":"bibr28-20503121241247471","unstructured":"R Core Team. 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