{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:52:47Z","timestamp":1790959967469,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Center of Cleft Lip-Cleft Palate and Craniofacial Deformities, Khon Kaen University under Tawanchai Royal Grant Project","award":["TWG6304"],"award-info":[{"award-number":["TWG6304"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate the efficacy of adjunctive intratympanic dexamethasone therapy in improving outcomes of myringotomy with ventilation tube insertion for bilateral otitis media with effusion in children with cleft palate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Children with cleft palate aged 2\u201312\u2009years were recruited. Dexamethasone or placebo was administered intratympanically based on randomized allocation, with contralateral ear receiving the alternate treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-three children with cleft palate (mean age: 33.04\u2009\u00b1\u200927.80\u2009months) were enrolled. Baseline demographics were comparable between groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Both dexamethasone and placebo groups demonstrated significant hearing level improvements at 1-month follow-up (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patients with otitis media with effusion duration \u2a7d 3\u2009months exhibited superior outcomes in the dexamethasone group (mean difference: \u22123.18\u2009dB\u2009HL, 95% CI: \u22124.88 to \u22121.49,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002). Patients with cleft palate without other anomalies demonstrated a significant improvement in the dexamethasone group (mean difference: \u22123.24\u2009dB\u2009HL, 95% CI: \u22125.04 to \u22121.43,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002). No significant differences in adverse events were observed between groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Early intratympanic dexamethasone injection adjunct to myringotomy with ventilation tube insertion is recommended for otitis media with effusion in children with cleft palate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121251348026","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T23:47:34Z","timestamp":1750376854000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Intratympanic steroid injection adjunct to myringotomy with ventilation tube insertion for otitis media with effusion in children with cleft palate \u2013 a matched pair randomized controlled trial"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2195-4837","authenticated-orcid":false,"given":"Patorn","family":"Piromchai","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutarat","family":"Anutragulchai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwanchanok","family":"Yimtae","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Srirompotong","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panida","family":"Thanawirattananit","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Otorhinolaryngology, Khon Kaen University, Muang Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815624407"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.07.015"},{"key":"e_1_3_3_4_2","article-title":"Ear, nose, throat and craniofacial diseases community services initiative of Khon Kaen University","volume":"99","author":"Piromchai P","year":"2016","unstructured":"Piromchai P, Kasemsiri P, Vatanasapt P, et al. Ear, nose, throat and craniofacial diseases community services initiative of Khon Kaen University. J Med Assoc Thai 2016; 99(Suppl 5): S81\u2013S85.","journal-title":"J Med Assoc Thai"},{"key":"e_1_3_3_5_2","first-page":"51","article-title":"Incidence and management of middle ear effusion in cleft palate patients","volume":"47","author":"Lokman S","year":"1992","unstructured":"Lokman S, Loh T, Said H, et al. Incidence and management of middle ear effusion in cleft palate patients. Med J Malaysia 1992; 47: 51\u201355.","journal-title":"Med J Malaysia"},{"key":"e_1_3_3_6_2","first-page":"77","article-title":"Ear, nose, throat, and craniofacial disease screening in primary school: Khon Kaen University 2017 initiative","volume":"101","author":"Piromchai P","year":"2018","unstructured":"Piromchai P, Laohasiriwong S, Saesiew P, et al. Ear, nose, throat, and craniofacial disease screening in primary school: Khon Kaen University 2017 initiative. J Med Assoc Thai 2018; 101: 77.","journal-title":"J Med Assoc Thai"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215122001232"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666120-00003"},{"key":"e_1_3_3_9_2","volume-title":"Otitis media with effusion: comparative effectiveness of treatments","author":"Berkman ND","year":"2013","unstructured":"Berkman ND, Wallace IF, Steiner MJ, et al. Otitis media with effusion: comparative effectiveness of treatments. Rockville, MD: Agency for Healthcare Research and Quality (US), 2013."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.04.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000212"},{"key":"e_1_3_3_12_2","first-page":"244","article-title":"The efficacy of adjuvant intratympanic steroid treatment for otitis media with effusion in children","volume":"20","author":"Amer HS","year":"2016","unstructured":"Amer HS, El-Anwar MW, Elfeky AE. The efficacy of adjuvant intratympanic steroid treatment for otitis media with effusion in children. Int Arch Otorhinolaryngol 2016; 20: 244\u2013247.","journal-title":"Int Arch Otorhinolaryngol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.07.015"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.57198"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(98)00179-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joto.2019.01.005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-016-3958-9"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813479772"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.adoms.2021.100036"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.113941"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200206000-00003"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.09.009"}],"container-title":["Sage Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121251348026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20503121251348026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121251348026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:30:38Z","timestamp":1777595438000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20503121251348026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":21,"alternative-id":["10.1177\/20503121251348026"],"URL":"https:\/\/doi.org\/10.1177\/20503121251348026","relation":{},"ISSN":["2050-3121","2050-3121"],"issn-type":[{"value":"2050-3121","type":"print"},{"value":"2050-3121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"article-number":"20503121251348026"}}