{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:50:59Z","timestamp":1777881059169,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute heart failure affects ~9% of patients with hematological malignancies. This study aimed to evaluate the impact of acute heart failure on in-hospital mortality among patients with hematological malignancies and to identify independent predictors of mortality in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The National Inpatient Sample (2016\u20132021) was queried for adults (\u2a7e18\u2009years of age) with hematological malignancies and those who experienced in-hospital mortality. Among these, we identified patients who were hospitalized with a diagnosis of acute heart failure. Univariate analysis and multivariate regression were employed to analyze the mortality risk. A\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009\u2a7d\u20090.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 40,246 patients with hematological malignancies who died in the hospital, the univariate analysis showed a higher in-hospital mortality in the acute heart failure cohort compared to the non-acute heart failure group (8.08% versus 4.52%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, after adjusting for sociodemographic factors and comorbidities, acute heart failure was associated with a lower risk of in-hospital mortality (OR 0.87, 95% CI 0.84\u20130.9,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Predictors of mortality in the acute heart failure cohort were age &gt;60\u2009years, hematopoietic stem cell transplant, severe sepsis, arrhythmias, infective endocarditis, bleeding from any source, acute respiratory failure, hepatic dysfunction, metabolic encephalopathy, and invasive ventilation (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01). On subgroup analysis, acute myeloid leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, and multiple myeloma had a higher in-hospital mortality in the acute heart failure cohort compared to the non-acute heart failure group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Acute heart failure in patients with hematological malignancies was associated with poor outcomes in the presence of severe sepsis, organ dysfunction, and the need for mechanical ventilation. Close monitoring and a multidisciplinary team approach are recommended to optimize the treatment plan for this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121251370940","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T03:40:02Z","timestamp":1760758802000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute heart failure in patients with hematologic malignancies: A nationwide analysis 2016\u20132021"],"prefix":"10.1177","volume":"13","author":[{"given":"Barath","family":"Prashanth Sivasubramanian","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Northeast Georgia Medical Center, Gainesville, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-5647","authenticated-orcid":false,"given":"Diviya Bharathi","family":"Ravikumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, ESIC Medical College and Postgraduate Institute of Medical Science and Research, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siva Naga S.","family":"Yarrarapu","sequence":"additional","affiliation":[{"name":"Geriatric Medicine, University of Texas Health Science Center at San Antonio, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragavendar","family":"Saravanabavanandan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Illinois College of Medicine Peoria (UICOMP), IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibthisam Ismail","family":"Sharieff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, ESIC Medical College and Postgraduate Institute of Medical Science and Research, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashvat","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepthi","family":"Karunakar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pondicherry Institute of Medical Sciences, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Visalakshi Kannathal","family":"Vairavan","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Medicine and Biology, Kazan Federal University, Republic of Tatarstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indrajith Devandra","family":"Balamurugan","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Tianjin Medical University, Heping District, P.R. 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