{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:11:56Z","timestamp":1782817916844,"version":"3.54.5"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Sanming Project of Medicinein Shenzhen","award":["SZSM202206006"],"award-info":[{"award-number":["SZSM202206006"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Sepsis-induced cardiomyopathy (SCM), a frequent complication of septic shock with mortality exceeding 40%, arises from catecholamine-driven cardiotoxicity, sympathetic hyperactivity, and inflammation-mediated biventricular dysfunction. Short-acting \u03b2\u2081-blockers (esmolol, landiolol) offer a targeted therapeutic approach by reducing heart rate (target: 80\u201395\u2009bpm), myocardial oxygen demand, and proinflammatory cytokines while improving diastolic perfusion\u2014leveraging ultra-short half-lives (t\u2081\/\u2082\u2009=\u20094\u20139\u2009min) for rapid reversibility during instability. Clinical evidence remains divergent: a landmark single-center RCT demonstrated significant 28-day mortality reduction (49.4% vs 80.5%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), improved hemodynamics, and reduced vasopressor requirements in hemodynamically stabilized patients, whereas premature termination of a multicenter trial revealed harm (increased vasopressor needs, mortality trend) when initiated during persistent hypoperfusion (lactate\u2009&gt;\u20092\u2009mmol\/L). Current limitations include heterogeneous trial designs, small samples, and undefined benefiting phenotypes. Thus, cautious short-acting \u03b2-blockade is supported only for selected SCM patients with hemodynamic stability (MAP\u2009\u2a7e65\u2009mmHg, normalized lactate, LVEF\u2009&gt;35%), necessitating future precision trials with AI phenotyping to guide mechanism-targeted application.\n                  <\/jats:p>","DOI":"10.1177\/20503121251413649","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T16:59:28Z","timestamp":1768755568000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Research progress on beta-blockers in the treatment of sepsis-induced cardiomyopathy: A mini review"],"prefix":"10.1177","volume":"14","author":[{"given":"LiHua","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, The People\u2019s Hospital of Baoan Shenzhen, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2217-8355","authenticated-orcid":false,"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The People\u2019s Hospital of Baoan Shenzhen, Shenzhen, China"},{"name":"Department of EICU, Shenzhen Baoan Air Sea Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CuiJie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The People\u2019s Hospital of Baoan Shenzhen, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QingLi","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The People\u2019s Hospital of Baoan Shenzhen, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.628302"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199703000-00021"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13050839"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181f204ca"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14093253"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00492-2"},{"issue":"6","key":"e_1_3_2_9_2","first-page":"607","article-title":"The role of the renin\u2013angiotensin system in sepsis-associated acute kidney injury: mechanisms and therapeutic implications","volume":"29","author":"Garcia B","year":"2023","unstructured":"Garcia B, Zarbock A, Bellomo R, et al. The role of the renin\u2013angiotensin system in sepsis-associated acute kidney injury: mechanisms and therapeutic implications. Curr Opin Crit Care 2023; 29(6): 607\u2013613.","journal-title":"Curr Opin Crit Care"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00735-2"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.735841"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-021-00553-9"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1068324"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.860"},{"issue":"2","key":"e_1_3_2_15_2","first-page":"212","article-title":"Research advance on the role of pro-inflammatory cytokines in sepsis","volume":"35","author":"Chen Y","year":"2023","unstructured":"Chen Y, Dong P, Zhang X. Research advance on the role of pro-inflammatory cytokines in sepsis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2023; 35(2): 212\u2013216.","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.783164"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05069-w"},{"issue":"10","key":"e_1_3_2_18_2","article-title":"Cardiac failure and cardiogenic shock: insights into pathophysiology, classification, and hemodynamic assessment","volume":"16","author":"Siopi SA","year":"2024","unstructured":"Siopi SA, Antonitsis P, Karapanagiotidis GT, et al. Cardiac failure and cardiogenic shock: insights into pathophysiology, classification, and hemodynamic assessment. 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