{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:51:26Z","timestamp":1777881086034,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The records from a network of mobile wound clinics were analyzed to evaluate the efficacy of a human placental-based allograft compared with the standard of care for patients with chronic pressure ulcer wounds and multiple comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>\n                      Real-world evidence from a mobile wound clinic (July 2022\u2013June 2023) was used to analyze patients with pressure ulcer wounds, most of whom received home-based wound care and had multiple comorbidities that worsened their chronic wounds. Patients were grouped into standard of care with debridement or standard of care with debridement and grafting intervention. After each visit, the wound area and depth were measured and recorded. Wounds were scored for granulation and epithelialization and eschar and slough during each visit. The standard of care with debridement and grafting cohort was monitored for graft duration, and the number of graft applications per wound was recorded. Statistical analysis used a paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test and ANOVA for multiple comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The standard of care with debridement and grafting cohort demonstrated an average percent change in wound area of 46% reduction, compared to a 42% increase in the standard of care (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean percent change in wound depth was a 36% reduction in the graft recipients versus a 37% increase in the standard of care with debridement (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Graft recipients improved their positive wound score by 8% (granulation and epithelialization), and decreased their negative wound score decreased by 55% (eschar and slough) after the final graft visit, compared with patients receiving standard of care with debridement. The average duration of the graft was 147\u2009days (\u00b18\u2009days), involving 22 applications (\u00b11.7) per wound.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We present real-world evidence demonstrating the use of placental-based grafts to reduce wound size in patients with chronic PU, multiple comorbidities and limited mobility. Our study highlights the importance of reviewing the current local coverage determination and making graft applications permissible based on patients\u2019 wound-care responses, thereby benefiting patient care and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261430126","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:26:42Z","timestamp":1773894402000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A retrospective real-world analysis of placental-based allografts on pressure ulcers"],"prefix":"10.1177","volume":"14","author":[{"given":"David","family":"Kay","sequence":"first","affiliation":[{"name":"West Coast Wound &amp; Skin Care, Burbank, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Sandres-Corwin","sequence":"additional","affiliation":[{"name":"West Coast Wound &amp; Skin Care, Burbank, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-5611","authenticated-orcid":false,"given":"Harry H.","family":"Matundan","sequence":"additional","affiliation":[{"name":"West Coast Wound &amp; Skin Care, Burbank, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0283-9318.2003.00250.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1157518"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-022-00597-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2016.0697"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1154567"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2013.22.7.347"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12843"},{"key":"e_1_3_2_9_2","article-title":"Dehydrated human amnion\/chorion membrane to treat venous leg ulcers: a cost-effectiveness analysis","volume":"33","author":"Tettelbach WH","year":"2024","unstructured":"Tettelbach WH, Driver V, Oropallo A, et al. Dehydrated human amnion\/chorion membrane to treat venous leg ulcers: a cost-effectiveness analysis. J Wound Care 2024; 33(suppl 3): S24\u2013S38.","journal-title":"J Wound Care"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12029"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1530443"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.7547\/17-039"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.Sup5.S4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000281"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.18869\/acadpub.beat.5.4.452"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000390"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1615\/JLongTermEffMedImplants.v14.i4.20"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.778"},{"issue":"10","key":"e_1_3_2_19_2","first-page":"12284","article-title":"Pathologic changes of wound tissue in rats with stage III pressure ulcers treated by transplantation of human amniotic epithelial cells","volume":"8","author":"Zheng X","year":"2015","unstructured":"Zheng X, Jiang Z, Zhou A, et al. Pathologic changes of wound tissue in rats with stage III pressure ulcers treated by transplantation of human amniotic epithelial cells. Int J Clin Exp Pathol 2015; 8(10): 12284\u201312291.","journal-title":"Int J Clin Exp Pathol"},{"issue":"8","key":"e_1_3_2_20_2","article-title":"Placental membrane provides improved healing efficacy and lower cost versus a tissue-engineered human skin in the treatment of diabetic foot ulcerations","volume":"7","author":"Glat P","year":"2019","unstructured":"Glat P, Orgill DP, Galiano R, et al. Placental membrane provides improved healing efficacy and lower cost versus a tissue-engineered human skin in the treatment of diabetic foot ulcerations. Plast Reconstr Surg Glob Open 2019; 7(8): e2371.","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.Sup7.S5"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.37871\/jbres1545"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0298-8"},{"key":"e_1_3_2_24_2","unstructured":"Centers for Medicare & Medicaid Services. Proposed LCD DL39764. Skin substitute grafts\/cellular and tissue-based products for the treatment of diabetic foot ulcers and venous leg ulcers https:\/\/localcoverage.cms.gov\/mcd_archive\/view\/lcd.aspx?lcdInfo=39763:9&keyword=DL39764&keywordType=starts&areaId=all&docType=6 0 3 5 1 F P&contractOption=all&sortBy=relevance&bc=1 (2024 accessed 1 December 2024)."}],"container-title":["Sage Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121261430126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20503121261430126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121261430126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:31:54Z","timestamp":1777595514000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20503121261430126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":23,"alternative-id":["10.1177\/20503121261430126"],"URL":"https:\/\/doi.org\/10.1177\/20503121261430126","relation":{},"ISSN":["2050-3121","2050-3121"],"issn-type":[{"value":"2050-3121","type":"print"},{"value":"2050-3121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"20503121261430126"}}