{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:51:23Z","timestamp":1777881083109,"version":"3.51.4"},"reference-count":59,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pain and trismus are common complications that significantly impair quality of life after mandibular third molar surgery. This study investigated the efficacy of only one preoperative dose of oral tizanidine, a centrally acting muscle relaxant having analgesic properties, in reducing these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Forty patients who needed surgical removal of bilateral impacted mandibular third molars were selected for a split-mouth, triple-blind, randomized clinical trial. Each patient was randomly assigned to receive 4\u2009mg tizanidine or a placebo 1\u2009h before surgery on one side. In the other surgery, the contralateral side was treated alternatively. The Visual Analog Scale (VAS) was used for pain assessment, and trismus was measured by maximum mouth opening (MMO) in millimeters at Days 1, 3, and 7 post-surgery. Paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test and repeated measures analysis of variance were used to analyze data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Tizanidine group had significantly lower mean VAS pain scores compared to the placebo group on the first postoperative day (3.30\u2009\u00b1\u20090.87 vs 5.25\u2009\u00b1\u20091.02;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Both groups experienced a decrease in pain scores over time, though the differences in Days 3 and 7 did not reach statistical significance. Nonetheless, the tizanidine group had significantly greater MMO (less trismus) than the control group at all postoperative time points (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A single dose of preoperative oral tizanidine provides a useful supplementary tool to diminish immediate postoperative pain and relieve trismus after surgical removal of mandibular third molars. Tizanidine can be included as an adjunct in multimodal techniques to improve patient comfort and recovery following oral surgeries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261433738","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:04:51Z","timestamp":1774883091000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of preoperative tizanidine on postoperative pain and trismus following surgical removal of mandibular third molar: A randomized clinical trial"],"prefix":"10.1177","volume":"14","author":[{"given":"Mohsen","family":"Golkar","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Latifi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-3264","authenticated-orcid":false,"given":"Amirmohammad","family":"Salamatmanesh","sequence":"additional","affiliation":[{"name":"Gifted and Talented Dental Students Division, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzan","family":"Zakermashhadi","sequence":"additional","affiliation":[{"name":"Gifted and Talented Dental Students Division, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"issue":"1","key":"e_1_3_3_2_2","first-page":"7","article-title":"Prevalence of impacted third molars in dental students","volume":"13","author":"Schersten E","year":"1989","unstructured":"Schersten E, Lysell L, Rohlin M. 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