{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:51:27Z","timestamp":1777881087694,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine the frequency and clinical associations of hypermobility spectrum disorders in a central orthopedic hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A clinical epidemiological, prospective hospital-based cross-sectional design was employed. Kuwait Ministry of Health Ethics Board approved the study (ref. no. 2022\/2233). The Beighton score and the 2017 hypermobility spectrum disorders classification framework were used for screening over a 7-month period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 270 patients were examined, revealing a hypermobility spectrum disorder frequency of 21.1%; 31.7% in women and 4.7% in men. The mean age\u2009\u00b1\u2009standard deviation was 39.4\u2009\u00b1\u200916.9\u2009years, and 91.2% of identified cases were women. Among individuals with hypermobility spectrum disorders, 63.2% were classified as generalized hypermobility spectrum disorders, 26.3% as localized hypermobility spectrum disorders, and 10.5% as peripheral hypermobility spectrum disorders. The most frequent primary diagnosis or injury involved the knee (45.3%), hand (19.4%), and foot and ankle (19.4%). The most frequent secondary diagnosis or injury involved the knee (40.6%) and foot and ankle (28.1%). The most frequent tertiary diagnosis or injury involved the knee (50.0%) and the spine (20.0%). Management was most commonly directed toward the knee (45.7%), followed by the foot and ankle (12.7%). Statistically significant associations were identified between the Beighton score and primary diagnosis or injury (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.032,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.284), secondary management (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.516), and tertiary management (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.027,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.690).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Hypermobility spectrum disorder was frequently observed in a central orthopedic hospital and showed significant associations with orthopedic diagnoses and management pathways, indicating a substantial clinical burden and implications for orthopedic service planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261437153","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:32:41Z","timestamp":1775565161000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A clinical epidemiological study of musculoskeletal injury occurrence and orthopedic management patterns among individuals with hypermobility spectrum disorders"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3313-2232","authenticated-orcid":false,"given":"Najla","family":"Alsiri","sequence":"first","affiliation":[{"name":"Health Sciences Center, Kuwait University, Kuwait"},{"name":"Alrazi Orthopedic Hospital, Capital Governance, Kuwait City, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Alhumaid","sequence":"additional","affiliation":[{"name":"Alrazi Orthopedic Hospital, Capital Governance, Kuwait City, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bouchra","family":"Maksoud","sequence":"additional","affiliation":[{"name":"Alrazi Orthopedic Hospital, Capital Governance, Kuwait City, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31539"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.2478\/rir-2023-0010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.63857"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26125587"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4193-0"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.152127"},{"key":"e_1_3_2_9_2","volume-title":"Collagen structure and mechanics","author":"Fratzl P.","year":"2008","unstructured":"Fratzl P. Collagen structure and mechanics. Springer, 2008."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.02.015"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-024-07172-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4314\/eamj.v79i2.8906"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0973369820060103"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.6.793"},{"issue":"1","key":"e_1_3_2_15_2","first-page":"43","article-title":"A study exploring the prevalence of joint hypermobility syndrome in patients attending a Musculoskeletal Triage Clinic","volume":"36","author":"Connelly E","year":"2014","unstructured":"Connelly E, Hakim E, Davenport S, et al. A study exploring the prevalence of joint hypermobility syndrome in patients attending a Musculoskeletal Triage Clinic. Physiother Pract Res 2014; 36(1): 43\u201353.","journal-title":"Physiother Pract Res"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/24.4.326"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/msc.184"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.1.56"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201108000-00002"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/230949901302100213"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38106"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04249-x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1192\/pb.bp.114.050203"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195305234.001.0001"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S5309"},{"issue":"5","key":"e_1_3_2_26_2","first-page":"543","article-title":"Hospital based epidemiological study for diabetic retinopathy: study design and preliminary results","volume":"4","author":"Liu L","year":"2011","unstructured":"Liu L, Liu LM, Hu YD, et al. Hospital based epidemiological study for diabetic retinopathy: study design and preliminary results. Int J Ophthalmol 2011; 4(5): 543\u2013545.","journal-title":"Int J Ophthalmol"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-091896"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.5.413"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2003.08.001"},{"issue":"11","key":"e_1_3_2_30_2","first-page":"119","article-title":"Beighton score: a valid measure for generalized hypermobility in children","volume":"158","author":"Smits-Engelsman B","year":"2010","unstructured":"Smits-Engelsman B, Klerks M, Kirby A. Beighton score: a valid measure for generalized hypermobility in children. J Pediatr 2010; 158(11): 119\u2013123.","journal-title":"J Pediatr"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-84882-085-2"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325967120968099"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.5.554"},{"issue":"4","key":"e_1_3_2_34_2","first-page":"804","article-title":"Epidemiology of general joint hypermobility and basis for the proposed criteria for benign joint hypermobility syndrome: review of the literature","volume":"34","author":"Remvig L","year":"2007","unstructured":"Remvig L, Jensen D, Ward R. Epidemiology of general joint hypermobility and basis for the proposed criteria for benign joint hypermobility syndrome: review of the literature. J Rheumatol 2007; 34(4): 804\u2013809.","journal-title":"J Rheumatol"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.math.2007.05.001"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1062808"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1320-y"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.08.003"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/JSA.0b013e318210c0aa"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199907001-00007"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-7535(01)00004-2"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/0309364620956866"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2016.01.011"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0194-9"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.4055\/cios20103"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2021.596971"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.4137\/CMAMD.S10859"}],"container-title":["Sage Open Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121261437153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/20503121261437153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/20503121261437153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:32:00Z","timestamp":1777595520000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/20503121261437153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":46,"alternative-id":["10.1177\/20503121261437153"],"URL":"https:\/\/doi.org\/10.1177\/20503121261437153","relation":{},"ISSN":["2050-3121","2050-3121"],"issn-type":[{"value":"2050-3121","type":"print"},{"value":"2050-3121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"article-number":"20503121261437153"}}