{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:51:26Z","timestamp":1777881086909,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"QIAGEN"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Latent tuberculosis infection, an infection caused by\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      , affects one-quarter of the world\u2019s population. The World Health Organization recommends screening for latent tuberculosis infection in at-risk populations to reduce morbidity and mortality risks associated with tuberculosis using the tuberculin skin test and interferon-gamma release assays, including the QuantiFERON-TB Gold Plus\n                      <jats:sup>\u00ae<\/jats:sup>\n                      test (QTF-Plus\n                      <jats:sup>\u00ae<\/jats:sup>\n                      test).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to assess the place of QTF-Plus test in latent tuberculosis infection screening among a high-risk population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 969 biotherapy candidates were included in the study (52.63% female and 47.36% male; sex ratio\u2009=\u20090.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age was 38.29\u2009\u00b1\u200915.83\u2009years. The frequency of latent tuberculosis infection, according to QTF-Plus test results, was 20.22%. Factors such as age and history of tuberculosis were significantly associated with QTF-Plus test results (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001, respectively). QTF-Plus test and tuberculin skin test were performed simultaneously on 632 patients. A weak agreement between these tests was found (77.50%, Cohen\u2019s kappa coefficient of 0.13). However, a good correlation between TB antigen tube 1 and TB antigen tube 2 (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.72,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0001; 95% CI: 0.68\u20130.74) was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings demonstrate that the QTF-Plus test is useful for latent tuberculosis infection screening in a highly vaccinated population with an intermediate prevalence of tuberculosis<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261440443","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:07:46Z","timestamp":1776841666000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Positivity rate of QuantiFERON-TB Gold Plus\n                    <sup>\u00ae<\/sup>\n                    test among candidates for biotherapy and factors influencing results"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5203-6618","authenticated-orcid":false,"given":"Hanane","family":"Mezenner","sequence":"first","affiliation":[{"name":"Immunology Department, Mustapha Bacha Teaching Hospital, Algiers, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiba","family":"Ait Hamoudi","sequence":"additional","affiliation":[{"name":"Immunology Department, Mustapha Bacha Teaching Hospital, Algiers, Algeria"},{"name":"University of Health Sciences, Algiers, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumia","family":"Naamoune","sequence":"additional","affiliation":[{"name":"Immunology Department, Mustapha Bacha Teaching Hospital, Algiers, Algeria"},{"name":"University of Health Sciences, Algiers, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriem","family":"Abbadi","sequence":"additional","affiliation":[{"name":"Immunology Department, Mustapha Bacha Teaching Hospital, Algiers, Algeria"},{"name":"University of Health Sciences, Algiers, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriem","family":"Khedimallah","sequence":"additional","affiliation":[{"name":"Immunology Department, Mustapha Bacha Teaching Hospital, Algiers, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kafia","family":"Belhocine","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Algiers, Algeria"},{"name":"Gastroenterology Department, Mustapha Bacha Teaching Hospital, Algiers, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Zobiri","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Algiers, Algeria"},{"name":"Dermatology Department, Mustapha Bacha Teaching Hospital, Algiers, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanis","family":"Meddour","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Algiers, Algeria"},{"name":"Central Laboratory, Military University Hospital of Oran, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia","family":"Taright","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Algiers, Algeria"},{"name":"Pneumology Department, Mustapha Bacha Teaching Hospital, Algiers, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofiane Samir","family":"Salah","sequence":"additional","affiliation":[{"name":"Immunology Department, Mustapha Bacha Teaching Hospital, Algiers, Algeria"},{"name":"University of Health Sciences, Algiers, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Tuberculosis","author":"World Health Organization","year":"2023","unstructured":"World Health Organization. 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