{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:16:06Z","timestamp":1778570166296,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Intoduction<\/jats:title>\n                    <jats:p>Endometriosis is a chronic inflammatory condition characterized by the presence of endometrial tissue outside the uterus, leading to pelvic pain and infertility. It affects approximately 10% of women of reproductive age. Endometriosis is associated with a chronic inflammatory process that results in pain, tissue remodelling, fibrosis, adhesions, and infertility. Numerous chronic inflammatory indicators can serve as practical prognostic and diagnostic biomarkers for the severity of the disease, one of which is the neutrophil-lymphocyte ratio (NLR). The normal range of NLR is 1\u20133, with mild stress falling within the range of 6\u20139, and critical conditions being indicated by values above 9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim of study<\/jats:title>\n                    <jats:p>This study aimed to investigate the association between endometriosis and the neutrophil-lymphocyte ratio (NLR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was conducted at Margono Soekarjo General Hospital in Indonesia and involved all women who suspected endometriosis between January 2022 and May 2024. Several inclusion and exclusion criteria were applied. Statistical analysis was peformed to calculate the odds ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study found that women with endometriosis had 4.80 times higher odds [OR 4.8, 95% CI, p = 0.001] of having an elevated NLR compared to those without endometriosis. This means that women with endometriosis have a 4.80 higher risk of having an elevated NLR compared to women without endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is a statistically significant association between endometriosis and NLR. NLR can serve as a biomarker with a potential role in the diagnosis and prognosis of endometriosis. Women with symptoms of endometriosis can undergo an NLR examination as a predictor or a pre-surgery assessment before confirmation through surgery and histopathological examination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261451323","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T06:53:21Z","timestamp":1778309601000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil-to-lymphocyte ratio (nlr) as a predictor of endometriosis occurrence and prognosis: Evidence from a single-center study in Indonesia"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-1238","authenticated-orcid":false,"given":"Ruswana","family":"Anwar","sequence":"first","affiliation":[{"name":"Universitas Padjadjaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rivaldi","family":"Rizal","sequence":"additional","affiliation":[{"name":"Universitas Padjadjaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6009-4999","authenticated-orcid":false,"given":"Dina","family":"Marlina","sequence":"additional","affiliation":[{"name":"Universitas Padjadjaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6512-9764","authenticated-orcid":false,"given":"Aditya","family":"Utomo","sequence":"additional","affiliation":[{"name":"Universitas Padjadjaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annisa Dewi","family":"Nugrahani","sequence":"additional","affiliation":[{"name":"Universitas Padjadjaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wianne","family":"Carima","sequence":"additional","affiliation":[{"name":"Bandung Islamic University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Alamsyah","family":"Aziz","sequence":"additional","affiliation":[{"name":"Universitas Padjadjaran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6877-0174","authenticated-orcid":false,"given":"Edy","family":"Priyanto","sequence":"additional","affiliation":[{"name":"Jenderal Soedirman University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4710-0478","authenticated-orcid":false,"given":"Megawati Albadly Ponco Dewi","family":"Poernomo","sequence":"additional","affiliation":[{"name":"Jenderal Soedirman University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_3_8_2_2","volume-title":"Endometriosis guideline of the European Society of Human Reproduction and Embryology","author":"ESHRE Endometriosis Guideline Development Group","year":"2022","unstructured":"ESHRE Endometriosis Guideline Development Group. Endometriosis guideline of the European Society of Human Reproduction and Embryology, 2022."},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-023-02692-7"},{"key":"e_1_3_8_4_2","volume-title":"StatPearls [Internet]. Treasure Island (FL)","author":"Tsamantioti ES","year":"2024","unstructured":"Tsamantioti ES, Mahdy H. Endometriosis. In: StatPearls [Internet]. Treasure Island (FL). StatPearls Publishing, 2024."},{"key":"e_1_3_8_5_2","first-page":"57","volume-title":"Robbins and Cotran pathologic basis of disease","author":"Kumar V","year":"2018","unstructured":"Kumar V, Abbas AK, Aster JC. Inflammation and repair. In: Robbins and Cotran pathologic basis of disease. 10th ed. : Elsevier Saunders, 2018, pp. 57\u201393.","edition":"10"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.03.061"},{"issue":"7","key":"e_1_3_8_7_2","first-page":"474","article-title":"Neutrophil-to-lymphocyte ratio: past, present and future perspectives","volume":"122","author":"Zahorec R","year":"2021","unstructured":"Zahorec R. Neutrophil-to-lymphocyte ratio: past, present and future perspectives. Bratisl Lek Listy 2021; 122(7): 474\u2013488. https:\/\/doi.org\/10.4149\/BLL_2021_078","journal-title":"Bratisl Lek Listy"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.06.067"},{"key":"e_1_3_8_9_2","first-page":"1","article-title":"Relationship between patient age and disease features in women with endometriosis","volume":"26","author":"Stochino-Loi E","year":"2019","unstructured":"Stochino-Loi E. Relationship between patient age and disease features in women with endometriosis. J Minim Invasive Gynecol 2019; 26: 1\u20139.","journal-title":"J Minim Invasive Gynecol"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/22840265241291120"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.04.021"},{"issue":"4","key":"e_1_3_8_12_2","first-page":"1586","article-title":"The relationship between age of menarche and body mass index with endometriosis incidence","volume":"6","author":"Usman F","year":"2022","unstructured":"Usman F, Reza SG, Handayani E. The relationship between age of menarche and body mass index with endometriosis incidence. 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