{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T07:14:50Z","timestamp":1783235690371,"version":"3.54.6"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82460085"],"award-info":[{"award-number":["82460085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224BAB206014"],"award-info":[{"award-number":["20224BAB206014"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Coronary artery ectasia (CAE) can lead to adverse clinical outcomes, including coronary spasm, thrombosis, dissection and myocardial ischaemia. In patients with isolated CAE\u2013 in the absence of coronary artery stenosis, clinical symptoms such as angina pectoris may still occur. This study aimed to investigate the relationship between clinical features and circulating inflammatory marker levels in patients with isolated CAE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing coronary angiography (CAG) who consented to participate underwent cardiovascular disease and risk assessment. The study enrolled 52 patients with isolated CAE and 25 control individuals with normal coronary angiograms. Coronary blood flow in the three groups was assessed using the Thrombolysis in Myocardial Infarction (TIMI) frame count. Levels of inflammatory markers-including C-reactive protein (CRP), interleukin-1\u03b2 (IL-1\u03b2), interleukin-8 (IL-8), IL-10 and tumor necrosis factor-alpha (TNF-\u03b1) \u2013 were measured in the circulating blood of symptomatic and asymptomatic patients with isolated CAE and compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Symptomatic patients with isolated CAE showed significantly higher circulating levels of IL-1\u03b2 and TNF-\u03b1 than asymptomatic patients (\n                      <jats:italic toggle=\"yes\">p&lt;<\/jats:italic>\n                      0.05). In addition, coronary TIMI frame counts were lower (indicating slower blood flow) in symptomatic patients compared with asymptomatic individuals (\n                      <jats:italic toggle=\"yes\">p&lt;<\/jats:italic>\n                      0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with isolated CAE, the presence of symptoms is associated with elevated circulating levels of pro-inflammatory markers such as IL-1\u03b2 and TNF-\u03b1, as well as reduced coronary blood flow.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261463207","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:16:32Z","timestamp":1782965792000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between clinical features of isolated coronary artery ectasia and circulating levels of inflammatory markers"],"prefix":"10.1177","volume":"14","author":[{"given":"Junping","family":"Ou","sequence":"first","affiliation":[{"name":"Ji\u2019an Central People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijia","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Basic Medical College of Jinggangshan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Ji\u2019an Central People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Basic Medical College of Jinggangshan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Basic Medical College of Jinggangshan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7319-5038","authenticated-orcid":false,"given":"Xiaolin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Basic Medical College of Jinggangshan University"},{"name":"Jiangxi Province Key Laboratory of Organ Development and Epigenetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Ji\u2019an Central People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095195"},{"key":"e_1_3_6_3_2","first-page":"636e640","article-title":"Coronary artery ectasia is related to coronary slow flow and inflammatory activation","volume":"233","author":"Natale D","year":"2014","unstructured":"Natale D, Giuseppe S, Andrea C, et al. 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