{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:17:56Z","timestamp":1787851076884,"version":"build-2784847793"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Innovation Project of Graduate Education in Shanxi Province","award":["2016BY075"],"award-info":[{"award-number":["2016BY075"]}]},{"name":"2023 Talent Introduction Support Program of Shanghai Pudong New Area Zhoupu Hospital","award":["ZP-XK-2023B-4"],"award-info":[{"award-number":["ZP-XK-2023B-4"]}]},{"name":"2023 Public Institution People\u2019s Livelihood Research Special Project, Pudong New Area Science and Technology Development Fund","award":["PKJ2023-Y12"],"award-info":[{"award-number":["PKJ2023-Y12"]}]},{"name":"2024Teaching Research Project for Faculty, Shanghai University of Medicine & dealth Sciences","award":["CFDZ20240025P"],"award-info":[{"award-number":["CFDZ20240025P"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>Infection-associated acute respiratory distress syndrome (ARDS) is a common and severe clinical disease in critical care medicine, with high mortality and a significant burden on intensive care resources. Current treatments mainly rely on supportive care, and there is still a lack of effective targeted drugs and diagnostic tools. Therefore, in-depth exploration of its molecular mechanisms and identification of key genes have important clinical significance.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To screen infectious ARDS key genes, construct a risk prediction model, and explore targeted drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We extracted GSE32707 data from the GEO database, analyzed infection-related ARDS samples and control samples, screened for differentially expressed genes, and identified signaling pathways using GO and KEGG methods. Core genes were subsequently selected for molecular docking using HadDOCK. Notably, this study integrates multiple analytical approaches, including differentially expressed gene analysis, pathway enrichment, ceRNA network construction, immune infiltration characterization, and molecular docking into a systematic framework, which to our knowledge has not been previously applied to infectious ARDS in a coordinated manner. By integrating ceRNA networks to reveal immune characteristics, we validated key gene expressions and predicted targeted therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In patients with infectious ARDS, 3,034 differentially expressed genes were identified, enriched in T cell receptors, autophagy, and the PI3K\/Akt\/mTOR signaling pathway. Network analysis pinpointed key genes including ATG5, AKT1, ATG7, and BMP9, with ATG5 strongly associated with CD4\n                      <jats:sup>+<\/jats:sup>\n                      T cells and BMP9 linked to NK cells. Validation revealed elevated expression of BMP9, AKT1, and ATG5 in ARDS patients, while ATG7 showed low expression, with these genes showing certain diagnostic potential that warrants further validation. Based on the modeling of key genes to predict disease risk, the calibration curve showed acceptable reliability. Molecular docking suggested that sorafenib could bind to these target genes at the molecular level, indicating its theoretical potential as a candidate worthy of further investigation, though this computational finding requires experimental validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BMP9, AKT1, ATG5, and ATG7 may contribute to ARDS pathogenesis through immune cell infiltration and signaling pathway regulation. The risk model and sorafenib-targeted strategy provide preliminary insights and new directions for clinical diagnosis and treatment though further validation is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261483984","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:19:56Z","timestamp":1787609996000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Screening of key genes in infectious ARDS and development of a disease risk prediction model"],"prefix":"10.1177","volume":"14","author":[{"given":"Xiaoyan","family":"Li","sequence":"first","affiliation":[{"name":"Shanghai Pudong New Area Zhoupu Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0749-7863","authenticated-orcid":false,"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Sinopharm Tongmei General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Shuozhou People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"e_1_3_7_3_2","first-page":"174","article-title":"Epidemiological trends of mechanically ventilated acute respiratory distress syndrome: incidence, mortality and outcomes","volume":"24","author":"Bardaj\u00ed-Carrillo M","year":"2025","unstructured":"Bardaj\u00ed-Carrillo M, L\u00f3pez-Herrero R, Aguilar G, et al. Epidemiological trends of mechanically ventilated acute respiratory distress syndrome: incidence, mortality and outcomes. Journal of Intensive Care 2025; 24: 174.","journal-title":"Journal of Intensive Care"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2019.08.003"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-37162-5"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S529689"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.895629"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000002478"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20180137"},{"issue":"11","key":"e_1_3_7_10_2","first-page":"1419","article-title":"Circulating BMP9 Protects the Pulmonary Endothelium During Inflammation-induced Lung Injury in Mice","volume":"203","author":"Wei L","year":"2020","unstructured":"Wei L, Lu L, Xudong Y, et al. Circulating BMP9 Protects the Pulmonary Endothelium During Inflammation-induced Lung Injury in Mice. American journal of respiratory and critical care medicine 2020; 203(11): 1419\u20131430.","journal-title":"American journal of respiratory and critical care medicine"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2410229122"},{"issue":"14","key":"e_1_3_7_12_2","first-page":"1846","article-title":"GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor","volume":"23","author":"Sean D","year":"2007","unstructured":"Sean D, S PM. GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor. 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