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Dietary capsaicin (CAP) has been demonstrated to mitigate obesity, while its impact on B cell immunity during obesity remains unexplored. This study aimed to investigate the restorative effect of CAP on B cells deficiency in obese mice, and explore the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>C57BL\/6J mice were fed a standard chow diet or a high-fat diet (HFD), and HFD-fed mice were orally administered CAP. Flow cytometry was employed to evaluate the effect of CAP on B cell function in HFD mice. RNA-seq, RT-qPCR, etc, were utilized to elucidate the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CAP not only ameliorated HFD-induced metabolic abnormalities, but also reversed the HFD-associated reduction in the population of intestinal germinal center (GC) and IgA\n                      <jats:sup>+<\/jats:sup>\n                      B cells. Consequently, CAP treatment rescued the impaired response to the T cell-dependent antigen in HFD-fed mice. Mechanistically, our results indicate that the effects of CAP are correlated with the upregulation of CXCL12\/CXCR4, a pathway critically involved in GC B cell migration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CAP alleviates insulin resistance and restores the impaired GC B cell in obese mice. These findings highlight a mechanism underlying the anti-obesity effect of CAP and lay a foundation for its clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261484415","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:04:25Z","timestamp":1788185065000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Capsaicin attenuates high-fat diet-induced impairment of B-cell immunity"],"prefix":"10.1177","volume":"14","author":[{"given":"Chengyu","family":"Yang","sequence":"first","affiliation":[{"name":"China Academy of Chinese Medical Sciences"},{"name":"Jiangxi Health Industry Institute of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenya","family":"Liu","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Xiong","sequence":"additional","affiliation":[{"name":"Nanchang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Li","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"},{"name":"Jiangxi Health Industry Institute of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Zhao","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"},{"name":"Jiangxi Health Industry Institute of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"},{"name":"Jiangxi Health Industry Institute of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silu","family":"Li","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"},{"name":"Jiangxi Health Industry Institute of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"},{"name":"Jiangxi Health Industry Institute of Traditional Chinese Medicine"},{"name":"China Academy of Chinese Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9842-9312","authenticated-orcid":false,"given":"Hengjun","family":"Hang","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences"},{"name":"Jiangxi Health Industry Institute of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2006.00230.x"},{"key":"e_1_3_7_3_2","first-page":"4","article-title":"Low-grade chronic inflammation: a shared mechanism for chronic","volume":"40","author":"Cifuentes M","year":"2025","unstructured":"Cifuentes M, Verdejo HE, Castro PF, et al. 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