{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T08:14:56Z","timestamp":1788077696959,"version":"build-2784847793"},"reference-count":52,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Youth Top Talent Project of Fujian Provincial Foal Eagle Program"},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2023QNA001"],"award-info":[{"award-number":["2023QNA001"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2020QH1149"],"award-info":[{"award-number":["2020QH1149"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to evaluate the association between time-of-day differences in blood lipids and acute kidney injury (AKI) in critically ill patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study enrolled 3,227 ICU patients. AKI was defined according to the KDIGO 2012 criteria. Cox regression, restricted cubic splines, Kaplan-Meier analysis, and stratified interaction analysis were used to assess the association between daytime\/nighttime levels of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides and AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Each 1 mg\/dL increase in HDL-C was associated with a 0.5% decrease in AKI risk [HR 0.995, 95% CI 0.993\u20130.998, P &lt; 0.001]. Each 1 mg\/dL increase in triglyceride was associated with a 0.1% increase in AKI risk [HR 1.001, 95% CI 1.000\u20131.001, P = 0.004]. LDL-C exhibited an L-shaped nonlinear relationship with AKI. At or below 47 mg\/dL (daytime), 58 mg\/dL (nighttime), and 48 mg\/dL (overall), lower LDL-C was associated with higher AKI risk, whereas above these thresholds, LDL-C was no longer associated with AKI risk [daytime: HR 0.977, 95% CI 0.964\u20130.991, P &lt; 0.001; nighttime: HR 0.992, 95% CI 0.985\u20130.998, P = 0.009; overall: HR 0.987, 95% CI 0.980\u20130.994, P &lt; 0.001].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher HDL-C levels were consistently associated with lower AKI incidence within 28 days after ICU admission. Higher nighttime and overall triglyceride levels were associated with higher AKI incidence. An L-shaped nonlinear relationship was observed between LDL-C and AKI risk, with thresholds at 47 mg\/dL (daytime), 58 mg\/dL (nighttime), and 48 mg\/dL (overall). These findings highlight a complex relationship between lipid metabolism and renal outcomes in critically ill patients and warrant confirmation through prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261484432","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:18:47Z","timestamp":1787858327000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between time-of-day plasma lipid measurements and acute kidney injury in critically ill patients: A retrospective cohort study"],"prefix":"10.1177","volume":"14","author":[{"given":"Chao","family":"Yang","sequence":"first","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital"},{"name":"Fujian Provincial Key Laboratory of Critical Care Medicine"},{"name":"Fujian Provincial Key Laboratory of Emergency Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Xu","family":"Wei","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Shantou University Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fang","family":"He","sequence":"additional","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Da","family":"Jiang","sequence":"additional","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3145-9888","authenticated-orcid":false,"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital"},{"name":"Fujian Provincial Key Laboratory of Critical Care Medicine"},{"name":"Fujian Provincial Center for Critical Care Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3934-7"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3680397"},{"key":"e_1_3_7_4_2","first-page":"8","article-title":"Lipid disorders in patients with renal failure: Role in cardiovascular events and progression of chronic kidney disease","volume":"6","author":"Visconti L","year":"2016","unstructured":"Visconti L, Benvenga S, Lacquaniti A, et al. 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