{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:24:58Z","timestamp":1789129498594,"version":"build-2803163510"},"reference-count":112,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Carbapenems are considered the last resort to treat life-threatening bacterial infections. However, their efficacy is increasingly compromised by carbapenemase-producing\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      (CPKP) and\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      (CPEC). Although these organisms have been reported in Ethiopia, the overall burden and distribution of carbapenemase-encoding genes remain unclear. This study aims to determine the pooled prevalence of CPKP and CPEC from both clinical and non-clinical samples in Ethiopia and to identify the most common carbapenemase-encoding genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search was conducted in electronic databases for studies published in English up to June 30, 2025. The review followed PRISMA guidelines and included 44 eligible studies. Quality assessment was performed using the Joanna Briggs Institute (JBI) checklist. The meta-analysis was performed using Comprehensive Meta-Analysis (CMA) software version 2, applying a random-effects model to estimate pooled prevalence. Heterogeneity and publication bias were evaluated using the I\n                      <jats:sup>2<\/jats:sup>\n                      statistic, funnel plot, and Egger\u2019s test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The pooled prevalence of CPKP and\/or CPEC in Ethiopia was 8.3% (95% CI: 6.3\u201310.9; I\n                      <jats:sup>2<\/jats:sup>\n                      = 86.41, p &lt; 0.001), with a higher prevalence in non-clinical samples (13.3%) than in clinical ones (8%). Six studies reported 60 carbapenemase-encoding genes in 51\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      isolates. The most dominant resistant gene was the\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM<\/jats:sub>\n                      metallo-\u03b2-lactamase type, accounting for 85%. The pooled prevalence of multidrug-resistant\n                      <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                      and\/or\n                      <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                      reported by studies included in the review was 78.4% (95% CI = 71-84.2, I\n                      <jats:sup>2<\/jats:sup>\n                      = 96.10, p&lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study reveals a high pooled prevalence of CPKP and CPEC in Ethiopia and high dominance of the\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM<\/jats:sub>\n                      carbapenemase gene. These findings underscore the need for enhanced antimicrobial resistance surveillance, infection prevention strategies, and stewardship interventions across both clinical and environmental settings.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/20503121261488385","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:31:51Z","timestamp":1788820311000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence, multidrug resistance patterns, and carbapenemase-encoding genes of carbapenemase-producing\n                    <i>Klebsiella pneumoniae<\/i>\n                    and\n                    <i>Escherichia coli<\/i>\n                    from clinical and non-clinical samples in Ethiopia: Systematic review and meta-analysis"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8631-5094","authenticated-orcid":false,"given":"Chalachew","family":"Genet","sequence":"first","affiliation":[{"name":"Bahir Dar University"},{"name":"Bahir Dar University"},{"name":"Bahir Dar University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendemagegn","family":"Enbiale","sequence":"additional","affiliation":[{"name":"Bahir Dar University"},{"name":"Bahir Dar University"},{"name":"Arba Minch University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rommerskirchen","sequence":"additional","affiliation":[{"name":"Heinrich-Heine-University"},{"name":"Arsi University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addisu","family":"Melese","sequence":"additional","affiliation":[{"name":"Bahir Dar University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baye Yirga","family":"Adugna","sequence":"additional","affiliation":[{"name":"Bahir Dar University"},{"name":"Department of Pharmacy, Bahir Dar Health Science College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeleke","family":"Ayenew","sequence":"additional","affiliation":[{"name":"TB, Mycology and Other Bacterial Research Division, Ethiopian Public Health Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiwot","family":"Tadesse","sequence":"additional","affiliation":[{"name":"Bahir Dar University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayeh","family":"Abera","sequence":"additional","affiliation":[{"name":"Bahir Dar University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-2877","authenticated-orcid":false,"given":"Endalkachew","family":"Nibret","sequence":"additional","affiliation":[{"name":"Bahir Dar University"},{"name":"Bahir Dar University"},{"name":"Bahir Dar University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-2189","authenticated-orcid":false,"given":"Abaineh Munshea","family":"Abitew","sequence":"additional","affiliation":[{"name":"Bahir Dar University"},{"name":"Bahir Dar University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.750662"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro818"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.33393\/dti.2020.2170","article-title":"Prevalence of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing gram-negative bacilli: A meta-analysis report in Ethiopia","volume":"14","author":"Abayneh M","year":"2020","unstructured":"Abayneh M, Worku T. 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