{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:15:03Z","timestamp":1781043303387,"version":"3.54.1"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p>A 37-year-old Caucasian male, HIV-infected (CDC A2) in 2012 and on antiretroviral therapy, presented for a follow-up visit. On physical examination, a barely discernible light-colored macular rash was observed on the trunk, not involving the palms and soles. However, clear maculo-papular lesions were present over the proximal volar aspect of both forearms. Furthermore, well-demarked purplish, opaque, rough, vertically ridged plaque-like lesions were observed over the proximal portions of fingernails. The patient reported that cutaneous and nail lesions had appeared about 2\u2009months prior and that he had engaged in unprotected sex 5\u2009months before. Serologic tests for syphilis resulted reactive. Intramuscular injection of benzathine penicillin G, 2.4\u2009million units, was administered once a week for 3\u2009weeks. One month after therapy, the rash was no longer present, and at 5\u2009months, nail abnormalities had disappeared. The clinical findings, the serologic results, and the disappearance of skin and nail lesions after the administration of penicillin strongly suggest that this HIV-infected patient had secondary or early late syphilis with skin and nail-plate involvement. We are experiencing a resurgence of syphilis as well as an increase in unusual and\/or forgotten clinical manifestations. Syphilis remains a diagnostically challenging disease<\/jats:p>","DOI":"10.1177\/2050313x18767229","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T07:10:49Z","timestamp":1522221049000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Non-primary nail-plate syphilis in an HIV-infected patient"],"prefix":"10.1177","volume":"6","author":[{"given":"Chiara","family":"Gabrielli","sequence":"first","affiliation":[{"name":"Infectious Disease Clinic, Department of Medicine, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cardaci","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinic, Department of Medicine, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Malincarne","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinic, Department of Medicine, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Bruna","family":"Pasticci","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinic, Department of Medicine, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,28]]},"reference":[{"key":"bibr1-2050313X18767229","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2005.01.015"},{"key":"bibr2-2050313X18767229","first-page":"168","volume":"59","author":"Starzycki Z.","year":"1983","journal-title":"Br J Vener Dis"},{"key":"bibr3-2050313X18767229","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1365-2133.1911.tb16669.x","volume":"23","author":"Admson HG","year":"1911","journal-title":"Br J Dermatol"},{"key":"bibr4-2050313X18767229","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620060088021"},{"key":"bibr5-2050313X18767229","doi-asserted-by":"publisher","DOI":"10.1159\/000449418"},{"key":"bibr6-2050313X18767229","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4801-3.00239-3"},{"key":"bibr7-2050313X18767229","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2013.793819"},{"key":"bibr8-2050313X18767229","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-017-1019-y"},{"key":"bibr9-2050313X18767229","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-015-0783-9"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18767229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X18767229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18767229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:35:14Z","timestamp":1777595714000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X18767229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":9,"alternative-id":["10.1177\/2050313X18767229"],"URL":"https:\/\/doi.org\/10.1177\/2050313x18767229","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"article-number":"2050313X18767229"}}