{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:53:12Z","timestamp":1777881192901,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome are chronic, debilitating diseases involving apocrine gland-bearing skin inflammation and bone inflammation, respectively. Although both often present with multiple comorbidities, single patient co-presentation is rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/Results:<\/jats:title>\n                    <jats:p>This study reports the 8-year treatment course of a 40-year-old man with hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, and reviews relevant literature. Initial oral and topical antibiotics had little effect. Intralesional corticosteroid injections were effective for localized inflammatory lesions but insufficient for hidradenitis suppurativa control. Adalimumab initiation and local excision of a persistent HS lesion led to stabilization. Adalimumab provided dramatic back pain improvement. Synovitis, acne, pustulosis, hyperostosis, osteitis was diagnosed; adalimumab continuation with subsequent methotrexate addition resulted in hidradenitis suppurativa-synovitis, acne, pustulosis, hyperostosis, osteitis control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Literature regarding comorbid hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome therapy is scarce but growing. Adalimumab, methotrexate, intralesional corticosteroid, and lifestyle changes successfully maintained a severe hidradenitis suppurativa\u2013synovitis, acne, pustulosis, hyperostosis, osteitis\u2013syndrome case. Further studies beyond a case-based review could yield more definitive treatment plans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2050313x18778723","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T01:30:15Z","timestamp":1527903015000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Hidradenitis suppurativa with SAPHO syndrome maintained effectively with adalimumab, methotrexate, and intralesional corticosteroid injections"],"prefix":"10.1177","volume":"6","author":[{"given":"Erika L","family":"Crowley","sequence":"first","affiliation":[{"name":"SKiN Centre for Dermatology, Peterborough, ON, Canada"},{"name":"Departments of Environmental & Life Sciences and Biochemistry, Trent University, Peterborough, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"O\u2019Toole","sequence":"additional","affiliation":[{"name":"SKiN Centre for Dermatology, Peterborough, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda J","family":"Gooderham","sequence":"additional","affiliation":[{"name":"SKiN Centre for Dermatology, Peterborough, ON, Canada"},{"name":"Queen\u2019s University, Kingston, ON, Canada"},{"name":"Probity Medical Research, Waterloo, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"bibr1-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1159\/000453355"},{"key":"bibr2-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.10.010"},{"key":"bibr3-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.01.010"},{"key":"bibr4-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2017.018"},{"key":"bibr5-2050313X18778723","first-page":"436","volume-title":"Dermatology","author":"Moschello S","year":"2012","edition":"3"},{"key":"bibr6-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"bibr7-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13740"},{"key":"bibr8-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0199-5"},{"issue":"2","key":"bibr9-2050313X18778723","first-page":"185","volume":"69","author":"Aieska De","year":"2011","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"bibr10-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130977"},{"key":"bibr11-2050313X18778723","first-page":"1","volume":"19","author":"Cianci F","year":"2017","journal-title":"Clin Rheumatol"},{"key":"bibr12-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9328-5"},{"key":"bibr13-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"bibr14-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1159\/000477207"},{"key":"bibr15-2050313X18778723","doi-asserted-by":"publisher","DOI":"10.1159\/000484408"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18778723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X18778723","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18778723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:35:30Z","timestamp":1777595730000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X18778723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":15,"alternative-id":["10.1177\/2050313X18778723"],"URL":"https:\/\/doi.org\/10.1177\/2050313x18778723","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"article-number":"2050313X18778723"}}