{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:53:14Z","timestamp":1777881194894,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>In recent years, an immune-mediated disorder involving IgG4 has been described, which targets multiple organs and explains a number of disorders previously regarded as \u201cidiopathic\u201d or of unknown origin. Furthermore, the discovery of IgG4-related disease (IgG4-RD) has placed a number of pathologies within its spectrum, linking symptoms and conditions formerly considered isolated. Reports of the manifestations of IgG4-RD in the head and neck are scarce. Otological manifestations have been reported, but only a handful of cases are available in the literature. This is the first report of recalcitrant serous otitis media secondary to IgG4-RD, confirmed by immunohistopathology. A case of IgG4-RD of the middle ear is presented, manifesting itself as recalcitrant serous otitis media. The case is presented from an otolaryngological and histopathological perspective and briefly reviews this rare disorder. The importance of the awareness of IgG4-RD resides mainly in the fact that it is a treatable condition. This can potentially improve the quality of life of a number of patients, some of whom may not have had a clear diagnosis. A favorable response to glucocorticoids has been reported. In cases of persistent symptoms, immunosuppressive therapy has been used with success.<\/jats:p>","DOI":"10.1177\/2050313x18791428","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T06:39:09Z","timestamp":1533191949000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["IgG4 disease of the ear: Report and review"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-0345","authenticated-orcid":false,"given":"Carolina","family":"Wuesthoff","sequence":"first","affiliation":[{"name":"Deafness Research, Kolling Institute of Medical Research and Department of Otolaryngology, Head and Neck Surgery, Royal North Shore Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Allende","sequence":"additional","affiliation":[{"name":"Department of Histopathology, Douglass Hanly Moir Pathology, Sydney, NSW, Australia"},{"name":"Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmal","family":"Patel","sequence":"additional","affiliation":[{"name":"Deafness Research, Kolling Institute of Medical Research and Department of Otolaryngology, Head and Neck Surgery, Royal North Shore Hospital, Sydney, NSW, Australia"},{"name":"Discipline of Surgery, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia"},{"name":"Department of ORL-Head and Neck Surgery, Macquarie University, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,8,2]]},"reference":[{"key":"bibr1-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0386-x"},{"key":"bibr2-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60720-0"},{"key":"bibr3-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2017.1290911"},{"key":"bibr4-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21697"},{"key":"bibr5-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2016.10.011"},{"key":"bibr6-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22486"},{"issue":"3","key":"bibr7-2050313X18791428","first-page":"1","volume":"2","author":"Barnado AL","year":"2014","journal-title":"J Investig Med High Impact Case Rep"},{"key":"bibr8-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2016.08.005"},{"key":"bibr9-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2011.4.1.52"},{"key":"bibr10-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0710-0"},{"key":"bibr11-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-009158."},{"key":"bibr12-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20215"},{"key":"bibr13-2050313X18791428","volume-title":"Overview of IgG4-related disease","author":"Stone JH","year":"2017"},{"key":"bibr14-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104708"},{"key":"bibr15-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2013.01.004"},{"key":"bibr16-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001420"},{"key":"bibr17-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2017.04.004"},{"key":"bibr18-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414526844"},{"key":"bibr19-2050313X18791428","doi-asserted-by":"publisher","DOI":"10.1002\/art.27435"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18791428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X18791428","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18791428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:35:44Z","timestamp":1777595744000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X18791428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":19,"alternative-id":["10.1177\/2050313X18791428"],"URL":"https:\/\/doi.org\/10.1177\/2050313x18791428","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"article-number":"2050313X18791428"}}