{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:53:20Z","timestamp":1777881200208,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Although rare, erythema induratum is the most common entity presenting as lobular panniculitis with vasculitis. It is usually caused by a hypersensitivity reaction to Mycobacterium tuberculosis, although other aetiologies have been reported. We present a case of a 73-year-old male with multiple recurring tender erythematous nodules on the backs of both calves and shins. Prior to arrival in our clinic, the patient underwent a 9-month course of isoniazid with no improvement and subsequently received a diagnosis of idiopathic erythema induratum. We performed an interferon-gamma release assay QuantiFERON-TB Gold which was positive for M. tuberculosis infection. The patient was successfully treated with ethambutol 1.6\u2009g for 1\u2009month; pyrazinamide 2\u2009g for 2\u2009months; and isoniazid 300\u2009mg, vitamin B6 25\u2009mg, and rifampin 600\u2009mg for 6\u2009months. This case highlights the utility of using interferon-gamma release assay QuantiFERON-TB Gold and a multidrug regiment over isoniazid in erythema induratum.<\/jats:p>","DOI":"10.1177\/2050313x18804076","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T10:42:48Z","timestamp":1539168168000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of QuantiFERON-TB Gold to determine the aetiology of idiopathic erythema induratum: A case report"],"prefix":"10.1177","volume":"6","author":[{"given":"Alisa","family":"Brandon","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Toronto Regional Dermatology and Wound Healing Clinic, Mississauga, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asfandyar","family":"Mufti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Garry","family":"Sibbald","sequence":"additional","affiliation":[{"name":"Toronto Regional Dermatology and Wound Healing Clinic, Mississauga, ON, Canada"},{"name":"Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,10,10]]},"reference":[{"key":"bibr1-2050313X18804076","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2013.WOUND4"},{"key":"bibr2-2050313X18804076","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2008.05.007"},{"key":"bibr3-2050313X18804076","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01332.x"},{"key":"bibr4-2050313X18804076","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12052"},{"key":"bibr5-2050313X18804076","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb02979.x"},{"key":"bibr6-2050313X18804076","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13148"},{"issue":"6","key":"bibr7-2050313X18804076","first-page":"629","volume":"95","author":"van Zyl L","year":"2015","journal-title":"Tuberc Edinb Scotl"},{"key":"bibr8-2050313X18804076","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.11.0374"},{"issue":"10","key":"bibr9-2050313X18804076","first-page":"1226","volume":"14","author":"LoBue PA","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"bibr10-2050313X18804076","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-232OC"},{"key":"bibr11-2050313X18804076","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2756"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18804076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X18804076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18804076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:35:59Z","timestamp":1777595759000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X18804076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":11,"alternative-id":["10.1177\/2050313X18804076"],"URL":"https:\/\/doi.org\/10.1177\/2050313x18804076","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"article-number":"2050313X18804076"}}