{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:53:23Z","timestamp":1777881203221,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Since its emergence as a chemotherapy agent, gemcitabine has been associated with cutaneous adverse reactions. Rash is reported to be the most common cutaneous adverse effect. Other reported cutaneous reactions in the literature include bullous dermatosis, pseudocellulitis, subacute cutaneous lupus alopecia, and palmar\u2013plantar erythrodysesthesia. Skin necrosis is a very rare adverse effect of this otherwise well-tolerated chemotherapeutic agent. In searching the literature, only one other case has been reported. In our report, we present a 74-year-old male with adenocarcinoma of the pancreas, status-post pancreaticoduodenectomy (Whipple procedure), who developed a rare case of skin necrosis of the lower leg 2 weeks after completing six cycles of monotherapy gemcitabine treatment.<\/jats:p>","DOI":"10.1177\/2050313x18809268","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T07:32:10Z","timestamp":1540884730000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Gemcitabine-induced skin necrosis"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-6855","authenticated-orcid":false,"given":"Maria Monica","family":"Haydock","sequence":"first","affiliation":[{"name":"Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saroj","family":"Sigdel","sequence":"additional","affiliation":[{"name":"Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toni","family":"Pacioles","sequence":"additional","affiliation":[{"name":"Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"issue":"4","key":"bibr1-2050313X18809268","first-page":"e323","volume":"165","author":"D\u2019epiro M","year":"2014","journal-title":"Clin Ter"},{"key":"bibr2-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.11.027"},{"key":"bibr3-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.4957"},{"key":"bibr4-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1086\/520684"},{"key":"bibr5-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/831616"},{"key":"bibr6-2050313X18809268","volume-title":"Robbins basic pathology: with STUDENT CONSULT online access, 9e (Robbins pathology)","author":"Kumar V","year":"2012","edition":"9"},{"key":"bibr7-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg744"},{"key":"bibr8-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050247"},{"key":"bibr9-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1517\/14740330802374262"},{"key":"bibr10-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00464-0"},{"key":"bibr11-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.5.726"},{"key":"bibr12-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200311000-00009"},{"key":"bibr13-2050313X18809268","doi-asserted-by":"publisher","DOI":"10.2478\/v10019-010-0020-1"},{"issue":"2","key":"bibr14-2050313X18809268","first-page":"75","volume":"8","author":"Claudy A.","year":"1998","journal-title":"Eur J Dermatol"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18809268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X18809268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X18809268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:36:04Z","timestamp":1777595764000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X18809268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":14,"alternative-id":["10.1177\/2050313X18809268"],"URL":"https:\/\/doi.org\/10.1177\/2050313x18809268","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"article-number":"2050313X18809268"}}