{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:53:24Z","timestamp":1777881204731,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Insulin autoimmune syndrome is an unusual cause of spontaneous hypoglycaemia in non-Asian populations. In the majority of cases, this syndrome appears a few weeks after the administration of drugs containing a sulfhydryl group. A strong association between this syndrome and HLA-DR4 has been shown. Only seven cases have been described in non-Asian patients. We report the first case of insulin autoimmune syndrome in an Argentine woman taking alfa-lipoic acid. She developed hypoglycaemic symptoms approximately 1\u2009month after starting therapy. Blood sampling collected during an episode of symptomatic hypoglycaemia showed low blood glucose level (2.39\u2009mmol\/L), high level of serum insulin (1971.55\u2009pmol\/L), inappropriately high level of C-peptide (2.36\u2009nmol\/L) and high levels of insulin antibodies (274.78\u2009IU\/mL). HLA-DNA typing identified DRB1*04:03. Due to the widespread use of alfa-lipoic acid for its antioxidant properties, clinicians should be aware that it may trigger an autoimmune hypoglycaemia in people with a genetic predisposition.<\/jats:p>","DOI":"10.1177\/2050313x18819601","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T03:40:04Z","timestamp":1545882004000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Insulin autoimmune syndrome in an Argentine woman taking \u03b1-lipoic acid: A case report and review of the literature"],"prefix":"10.1177","volume":"6","author":[{"given":"Valentina","family":"Izzo","sequence":"first","affiliation":[{"name":"Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of 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