{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:21:09Z","timestamp":1792441269198,"version":"4.5.0"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Minocycline is a medication commonly used for the treatment of acne vulgaris. The central nervous system-induced side effects of minocycline include headaches, pseudotumor cerebri, ataxia, and vestibular dysfunction. Many minocycline-related side effects have been presented in the literature, however, reports of depersonalization symptoms induced by the medication are rare. We present the case of a 37-year-old female diagnosed with perioral dermatitis treated with minocycline, who within 1\u2009week suffered from severe depersonalization symptoms. The pathophysiologic mechanism of depersonalization induced by minocycline is unclear but various hypotheses include hypersensitivity of the serotonin system, drug-related metabolic encephalopathy, substance-induced temporal disintegration, and panic-disorder-related etiology. Depersonalization is a potentially severe and important side effect of minocycline that should be documented, further investigated, and recognized by clinicians.<\/jats:p>","DOI":"10.1177\/2050313x18823827","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:39:33Z","timestamp":1547771973000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Minocycline-induced transient depersonalization: A case report"],"prefix":"10.1177","volume":"7","author":[{"given":"Yassein","family":"Shamout","sequence":"first","affiliation":[{"name":"Division of Dermatology, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Sigal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan V","family":"Litvinov","sequence":"additional","affiliation":[{"name":"Division of Dermatology, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"bibr1-2050313X18823827","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12139"},{"key":"bibr2-2050313X18823827","doi-asserted-by":"publisher","DOI":"10.2165\/11632000-000000000-00000"},{"key":"bibr3-2050313X18823827","doi-asserted-by":"crossref","unstructured":"Fanning WL, Gump DW, Sofferman RA. Side effects of minocycline: a double-blind study. Antimicrob Agents Chemother 1977; 11(4): 712\u2013717. 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