{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:20:17Z","timestamp":1759940417429,"version":"3.41.2"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p> In this study, we report a case of a 50-year-old Japanese man who had chronic whiplash-associated disorder, hyperlipidaemia, hyperuricacidaemia, and mild liver dysfunction due to excessive alcohol intake. Recently, he developed mild tremor in his left hand. Initiation of clonazepam (0.5\u2009mg once daily before bedtime) helped to gradually ameliorate the tremor. However, 13\u2009days after clonazepam initiation, his liver function and lipid profiles aggravated, and his postprandial glucose level increased to 400\u2009mg\/dL. Clonazepam was stopped promptly, and at 7\u2009days after discontinuation, the abnormal triglyceride levels, liver dysfunction, and glycometabolism improved without any other medical intervention. This case may provide information on cautious use of clonazepam. When clonazepam is used for patients with existing hyperlipidaemia and liver dysfunction, it may cause abnormal lipid profile, aggravate liver dysfunction, and lead to remarkable glucose elevation. <\/jats:p>","DOI":"10.1177\/2050313x19842976","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T11:41:37Z","timestamp":1554723697000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Clonazepam-induced liver dysfunction, severe hyperlipidaemia, and hyperglycaemic crisis: A case report"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3043-2720","authenticated-orcid":false,"given":"Miyako","family":"Kishimoto","sequence":"first","affiliation":[{"name":"Clinical Research Center, Department of Medicine, International University of Health and Welfare, Tokyo, Japan"},{"name":"Department of Internal Medicine, Sanno Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Adachi","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Department of Medicine, International University of Health and Welfare, Tokyo, Japan"},{"name":"Gastroenterology Center, Sanno Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sanno Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Washizaki","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Department of Medicine, International University of Health and Welfare, Tokyo, Japan"},{"name":"Department of Internal Medicine, Sanno Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"bibr1-2050313X19842976","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197810122991505"},{"key":"bibr2-2050313X19842976","unstructured":"KLONOPIN TABLETS (clonazepam), https:\/\/www.gene.com\/download\/pdf\/klonopin_prescribing.pdf (2017, accessed 6 March 2019)."},{"key":"bibr3-2050313X19842976","first-page":"576","volume":"83","author":"Olsson R","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"bibr4-2050313X19842976","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040803"},{"key":"bibr5-2050313X19842976","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.16-6-s104"},{"key":"bibr6-2050313X19842976","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-016-0427-8"},{"key":"bibr7-2050313X19842976","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/168905"},{"key":"bibr8-2050313X19842976","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1252749"},{"key":"bibr9-2050313X19842976","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010014"},{"key":"bibr10-2050313X19842976","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90101-6"},{"key":"bibr11-2050313X19842976","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90102-7"},{"key":"bibr12-2050313X19842976","unstructured":"Product Information Lipidil, http:\/\/www.medicines.org.au\/files\/goplipid.pdf (accessed 6 March 2019)."},{"key":"bibr13-2050313X19842976","unstructured":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 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