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Topical 5-fluorouracil 1% was planned four times daily for 1\u2009week followed by 3\u2009weeks off-treatment. Patient inadvertently continued 5-fluorouracil, four times daily for 4\u2009weeks, presenting with clinical resolution of the ocular surface squamous neoplasia and subtotal corneal epithelial defect associated with 5-fluorouracil toxicity. One\u2009month later, we observed a transparent cornea and no signs of toxicity. 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