{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:41:02Z","timestamp":1753882862404,"version":"3.41.2"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> High-grade squamous intraepithelial lesion of the vulva is a premalignant condition which may be especially resistant to treatments among immunosuppressed patients. We present our experience with the use of topical cidofovir in a refractory case of extensive vulvar high-grade squamous intraepithelial lesion in a 37-year-old transplant patient. Eighteen cycles of cidofovir over a 2-year period led to a sustained significant improvement, mainly of the mucosal lesions and was well tolerated. To our knowledge, we have not seen this therapy described in transplant patients with extensive high-grade squamous intraepithelial lesion. <\/jats:p>","DOI":"10.1177\/2050313x20904542","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T06:54:10Z","timestamp":1581922450000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Refractory extensive vulvar high-grade squamous intraepithelial lesion in an immunosuppressed transplant patient treated with topical cidofovir: A case report"],"prefix":"10.1177","volume":"8","author":[{"given":"Darosa","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Dermatology, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Belisle","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deana","family":"Funaro","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,16]]},"reference":[{"key":"bibr1-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9418-8"},{"key":"bibr2-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000132"},{"key":"bibr3-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000169"},{"key":"bibr4-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.07.010"},{"key":"bibr5-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000984"},{"key":"bibr6-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.3727\/096504001108747855"},{"key":"bibr7-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205006"},{"key":"bibr8-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.07.127"},{"key":"bibr9-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835a9b16"},{"key":"bibr10-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70456-5"},{"key":"bibr11-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15124"},{"key":"bibr12-2050313X20904542","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652020-00006"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20904542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X20904542","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20904542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T16:47:52Z","timestamp":1740934072000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X20904542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":12,"alternative-id":["10.1177\/2050313X20904542"],"URL":"https:\/\/doi.org\/10.1177\/2050313x20904542","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2050313X20904542"}}