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In this case series, three painful chronic and ischemic wounds that were caused by polyarteritis nodosa vasculitis ( n\u2009=\u20091) and peripheral arterial disease (PAD) ( n\u2009=\u20092) were successfully treated with cryopreserved umbilical cord tissue and\/or amniotic membrane and umbilical cord particulate, resulting in notable reduction in pain within 7\u2009days followed by expedited wound closure. No adverse events related to these tissue products were observed. These preliminary data demonstrate its safety and efficacy in reducing pain and promoting wound healing in painful chronic and ischemic wounds. <\/jats:p>","DOI":"10.1177\/2050313x20910599","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T17:55:27Z","timestamp":1588010127000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of painful chronic wounds with amniotic and umbilical cord tissue: A case series"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-6404","authenticated-orcid":false,"given":"Pablo","family":"Acevedo","sequence":"first","affiliation":[{"name":"Florida Hospital North Pinellas Wound Healing Institute of Trinity, New Port Richey, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"bibr1-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05222.x"},{"key":"bibr2-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"bibr3-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07265.x"},{"key":"bibr4-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02276.x"},{"key":"bibr5-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000530069.82749.e5"},{"key":"bibr6-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2014.23.12.601"},{"key":"bibr7-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12405"},{"key":"bibr8-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2007.00311.x"},{"key":"bibr9-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2004.13.Sup2.13235"},{"issue":"2","key":"bibr10-2050313X20910599","first-page":"57","volume":"50","author":"Ribu L","year":"2004","journal-title":"Ostomy Wound Manage"},{"key":"bibr11-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.1994.3.6.294"},{"key":"bibr12-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1054\/cein.2001.0185"},{"key":"bibr13-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2702.2003.00859.x"},{"key":"bibr14-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70134-2"},{"issue":"3","key":"bibr15-2050313X20910599","first-page":"115","volume":"26","author":"Szor JK","year":"1999","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"bibr16-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1097\/00002800-200005000-00006"},{"key":"bibr17-2050313X20910599","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000410689.60105.7d"},{"key":"bibr18-2050313X20910599","unstructured":"Office HP. 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