{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:41:33Z","timestamp":1753882893226,"version":"3.41.2"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> A 60-year-old male presented with a history of a relatively hard and cystic right chest mass that had gradually increased in size, with subsequent skin erosion, exudate and hemorrhage. The cytologic specimens from a cyst fluid contained a large number of sheet-like or papillary clusters of atypical cuboidal to columnar epithelial cells with loss of myoepithelial components, in a severely inflammatory background with scattered siderophages. We first interpreted it as a carcinoma, but could not completely exclude out the possibilities of benign. Tumor extirpation was performed, and a gross examination of the neoplasm revealed a giant, cystic and partly solid papillary-projected tumor lesion, with a gray-whitish cut surface, associated focally with skin invasion, measuring approximately 9\u2009\u00d7\u20097\u2009cm with a 6\u2009\u00d7\u20094\u2009cm solid area in diameter. On a microscopic examination, solid parts of the tumor were predominantly composed of the intracystic proliferation of mildly atypical epithelial cells with absence of two-cell patterns in a papillary or papillotubular growth fashion, only partly involving the dermis to epidermis. Immunohistochemistry showed that the carcinoma cells were specifically positive for estrogen and progesterone receptors, whereas negative for p63, S-100 protein and several neuroendocrine markers. Therefore, we finally made a diagnosis of invasive intracystic carcinoma of the male breast. We should be aware that owing to its characteristic cytological features, cytopathologists might be able to make a correct diagnosis of that, based on multiple and adequate samplings, even though a core biopsy would be the absolute minimum assessment. <\/jats:p>","DOI":"10.1177\/2050313x20932005","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T07:10:05Z","timestamp":1591513805000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A unique surgical case of giant invasive intracystic carcinoma of the male breast focusing on cytological findings"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-5368","authenticated-orcid":false,"given":"Akihiro","family":"Shioya","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Uchinada, Japan"},{"name":"Department of Pathology, Kanazawa Medical University Hospital, Uchinada, Japan"},{"name":"Department of Pathology, Kanazawa Medical University Himi Municipal Hospital, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Kadoguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kanazawa Medical University Himi Municipal Hospital, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Uchinada, Japan"},{"name":"Department of Pathology, Kanazawa Medical University Hospital, Uchinada, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Ukihashi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kanazawa Medical University Himi Municipal Hospital, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Kanazawa Medical University Himi Municipal Hospital, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Inokuchi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Kanazawa Medical University Himi Municipal Hospital, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-0024","authenticated-orcid":false,"given":"Sohsuke","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Uchinada, Japan"},{"name":"Department of Pathology, Kanazawa Medical University Hospital, Uchinada, Japan"},{"name":"Department of Pathology, Kanazawa Medical University Himi Municipal Hospital, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,7]]},"reference":[{"key":"bibr1-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)00941-8"},{"key":"bibr2-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21353"},{"key":"bibr3-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20312"},{"key":"bibr4-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.1007\/BF02469496"},{"key":"bibr5-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-018-1318-5"},{"key":"bibr6-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10209"},{"key":"bibr7-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90250-X"},{"key":"bibr8-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/378157"},{"key":"bibr9-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2016.6050"},{"key":"bibr10-2050313X20932005","doi-asserted-by":"publisher","DOI":"10.5795\/jjscc.38.342"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20932005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X20932005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20932005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T11:44:24Z","timestamp":1740829464000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X20932005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":10,"alternative-id":["10.1177\/2050313X20932005"],"URL":"https:\/\/doi.org\/10.1177\/2050313x20932005","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2050313X20932005"}}