{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:06:32Z","timestamp":1790435192716,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> The \u03b1<jats:sub>1<\/jats:sub>-adrenergic antagonist prazosin has showed good effect against posttraumatic stress disorder\u2013related nightmares in several randomized controlled trials. The \u03b1<jats:sub>1<\/jats:sub>-adrenergic antagonist doxazosin, which has a longer half-live than prazosin, has received far less attention in the treatment of such nightmares. Here, we report a case of a patient suffering from severe nightmares following an erroneous medical administration of adrenaline (causing severe physiological hyper-activation) who was treated with doxazosin. Over a period of 280\u2009days, the patient kept a nightmare diary and took 0, 4, or 8\u2009mg doxazosin. The analyses showed that 8\u2009mg doxazosin (55.2% nightmare-free nights) worked better (odds ratio\u2009=\u200928.2; 95% confidence interval\u2009=\u20093.7\u2013213.9) compared to nights without doxazosin (4.3% nightmare-free nights). Except dizziness, which was not regarded as particularly bothersome by the patient, doxazosin was well tolerated. It is concluded that doxazosin may be indicated as a pharmacological treatment for patients suffering from posttraumatic stress disorder\u2013related nightmares. <\/jats:p>","DOI":"10.1177\/2050313x20936079","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T10:31:23Z","timestamp":1593426683000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Doxazosin for the treatment of nightmare disorder: A diary-based case study"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5831-0840","authenticated-orcid":false,"given":"St\u00e5le","family":"Pallesen","sequence":"first","affiliation":[{"name":"Department of Psychosocial Science, University of Bergen, Bergen, Norway"},{"name":"Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde Sofie","family":"Hamre","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Lang","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Bjorvatn","sequence":"additional","affiliation":[{"name":"Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"bibr1-2050313X20936079","volume-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2014","edition":"3"},{"key":"bibr2-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00071-4"},{"key":"bibr3-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.12.018"},{"key":"bibr4-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.032"},{"key":"bibr5-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12081133"},{"key":"bibr6-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.07.001"},{"key":"bibr7-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507598"},{"key":"bibr8-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-017-0078-4"},{"issue":"2","key":"bibr9-2050313X20936079","first-page":"PCC.11r01222","volume":"14","author":"Hudson SM","year":"2012","journal-title":"Prim Care Companion CNS Disord"},{"key":"bibr10-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1101\/lm.045898.117"},{"key":"bibr11-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181c827ae"},{"issue":"5","key":"bibr12-2050313X20936079","first-page":"PCC.12l01356","volume":"14","author":"Sethi R","year":"2012","journal-title":"Prim Care Companion CNS Disord"},{"key":"bibr13-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09681"},{"issue":"1","key":"bibr14-2050313X20936079","first-page":"26","volume":"50","author":"Roepke S","year":"2017","journal-title":"Pharmacopsychiatry"},{"key":"bibr15-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00067.x"},{"key":"bibr16-2050313X20936079","doi-asserted-by":"publisher","DOI":"10.3928\/00485713-20160728-01"},{"key":"bibr17-2050313X20936079","volume-title":"The ICD-10 classification of mental and behavioural disorders. 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