{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T08:42:25Z","timestamp":1773736945352,"version":"3.50.1"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> We report a case of an elderly Caucasian male with past medical history of dextrocardia with situs inversus totalis, polymyalgia rheumatica, history of cryptogenic stroke, and severe mitral regurgitation with mitral valve prolapse, who presented with acute heart failure symptoms, including severe dyspnea on exertion and worsening lower extremity edema in the setting of immunosuppression with steroids for a year-old diagnosis of polymyalgia rheumatica. One month prior to this presentation, the patient suffered a transient ischemic attack and during the workup, his transthoracic echocardiography showed myxomatous degeneration of posterior mitral leaflet, partially flail, with severe mitral regurgitation, which required mitral valve replacement. Genome sequencing of mitral valve anterior leaflet pathology detected Tropheryma whipplei as a causal agent of culture-negative endocarditis. The patient was treated with 6\u2009weeks of ceftriaxone and ampicillin\u2013sulbactam and further continued trimethoprim\u2013sulfamethoxazole for 1\u2009year. He continued antibiotic treatment with resolution of shortness of breath along with arthralgia. <\/jats:p>","DOI":"10.1177\/2050313x20936952","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T08:43:10Z","timestamp":1593506590000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["A rare case of Whipple\u2019s disease with endocarditis in a patient with dextrocardia"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-8132","authenticated-orcid":false,"given":"Abigayle","family":"Sullivan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Reading Hospital\u2014Tower Health System, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pragya","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Reading Hospital\u2014Tower Health System, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-2827","authenticated-orcid":false,"given":"Sijan","family":"Basnet","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Reading Hospital\u2014Tower Health System, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Herb","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Reading Hospital\u2014Tower Health System, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Zagorski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Reading Hospital\u2014Tower Health System, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"bibr1-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13140"},{"key":"bibr2-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra062477"},{"key":"bibr3-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05531-11"},{"key":"bibr4-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1078-6"},{"key":"bibr5-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/478349"},{"key":"bibr6-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.04.059"},{"key":"bibr7-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2014.11.011"},{"key":"bibr8-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.43"},{"key":"bibr9-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs116"},{"key":"bibr10-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1086\/322666"},{"key":"bibr11-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1080\/00365540110026764"},{"key":"bibr12-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01776-6"},{"key":"bibr13-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-245"},{"key":"bibr14-2050313X20936952","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0746-x"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20936952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X20936952","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20936952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T17:47:33Z","timestamp":1741024053000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X20936952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":14,"alternative-id":["10.1177\/2050313X20936952"],"URL":"https:\/\/doi.org\/10.1177\/2050313x20936952","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2050313X20936952"}}