{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:41:37Z","timestamp":1753882897305,"version":"3.41.2"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> Macular hemorrhage can occur spontaneously and repeatedly without choroidal neovascularization or other known lesions associated with myopia. We report a case of repeated myopic macular hemorrhage following fish oil supplementation. A 32-year-old male was referred with newly acquired paracentral scotoma in the left eye. Serial retinal imaging, including fundus photography, fluorescein angiography, and spectral-domain optical coherence tomography were performed. Fundus photography and fluorescein angiography showed a subtle red-colored lesion nasal to the fovea. Optical coherence tomography showed a dome shaped elevation in the ellipsoid zone and interdigitation zone in the left eye. No known ocular risk factors for macular hemorrhage, such as choroidal neovascularization, lacquer cracks, Fuch\u2019s spot or choroid thinning or keratoconus were observed. After 2 months without any treatment, the left eye lesion disappeared. However 2 weeks later, another newly developed red-colored lesion close to the left fovea was observed. At that moment, the detailed medical history revealed that the patient had been regularly taking a high dose of commercially available fish oil supplement beginning one month before the first macular hemorrhage. After discontinuation of the fish oil, the second left hemorrhage resolved gradually over the following 8 weeks. No recurrent hemorrhages have been detected at the 12 months follow-up visits. Our observations suggest that the relative value of nutritional supplementation with high doses of fish oil should be cautioned in patients with repetitive retinal hemorrhage. <\/jats:p>","DOI":"10.1177\/2050313x20952974","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T07:39:08Z","timestamp":1600155548000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Fish oil supplementation and repeated macular hemorrhage without choroidal neovascularization: A case report"],"prefix":"10.1177","volume":"8","author":[{"given":"Shi-Ying","family":"Li","sequence":"first","affiliation":[{"name":"Southwest Hospital\/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. China"},{"name":"Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Fujinami","sequence":"additional","affiliation":[{"name":"Laboratory of Visual Physiology, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan"},{"name":"Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila G","family":"Crewther","sequence":"additional","affiliation":[{"name":"School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-3311","authenticated-orcid":false,"given":"Yan-Ling","family":"Long","sequence":"additional","affiliation":[{"name":"Southwest Hospital\/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, P.R. 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China"},{"name":"Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"bibr1-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12658"},{"key":"bibr2-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318285cc24"},{"key":"bibr3-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181bd2fe4"},{"key":"bibr4-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1007\/BF02022993"},{"key":"bibr5-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.09.003"},{"key":"bibr6-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00014"},{"key":"bibr7-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-4-58"},{"key":"bibr8-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.2013-0204"},{"key":"bibr9-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)89130-8"},{"key":"bibr10-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.5.2248"},{"key":"bibr11-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008852127668"},{"key":"bibr12-2050313X20952974","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812792"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20952974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X20952974","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20952974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T22:23:00Z","timestamp":1740781380000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X20952974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":12,"alternative-id":["10.1177\/2050313X20952974"],"URL":"https:\/\/doi.org\/10.1177\/2050313x20952974","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2050313X20952974"}}