{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:32:50Z","timestamp":1768343570699,"version":"3.49.0"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> The use of venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, for the management of depression in women of childbearing age has been on the rise, and there have been multiple case reports in the literature tying venlafaxine in-utero exposure to a form of neonatal encephalopathy presenting as neonatal abstinence syndrome. We present the case of a 5-day-old term infant whose mother was on venlafaxine throughout her pregnancy and presented with hypothermia, poor feeding, and decreased activity level. She subsequently had a negative sepsis workup and required nasogastric tube feedings for 2\u2009weeks with spontaneous recovery and no clinical sequelae post-discharge. This case highlights the non-trivial potential risk of venlafaxine withdrawal in exposed newborns and the need for close observation. We propose a management framework for such situations in affected infants. <\/jats:p>","DOI":"10.1177\/2050313x20952981","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T05:44:31Z","timestamp":1598593471000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Venlafaxine-induced encephalopathy in term newborn"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1630-4004","authenticated-orcid":false,"given":"Walid M","family":"Maalouli","sequence":"first","affiliation":[{"name":"Division of Pediatric Hospital Medicine, Department of Pediatrics, Masonic Children\u2019s Hospital, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S","family":"Hilliard","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hospital Medicine, Department of Pediatrics, Masonic Children\u2019s Hospital, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"bibr1-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Muzik M, Hamilton SE. Use of antidepressants during pregnancy? What to consider when weighing treatment with antidepressants against untreated depression. Matern Child Health J 2016; 20(11): 2268\u20132279, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27461022 (accessed 2 October 2019).","DOI":"10.1007\/s10995-016-2038-5"},{"key":"bibr2-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Andrade SE, Reichman ME, Mott K, et al. Use of selective serotonin reuptake inhibitors (SSRIs) in women delivering liveborn infants and other women of child-bearing age within the U.S. Food and Drug Administration\u2019s Mini-Sentinel program. Arch Womens Ment Health 2016; 19(6): 969\u2013977, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27178125 (accessed 2 October 2019).","DOI":"10.1007\/s00737-016-0637-1"},{"key":"bibr3-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Holland J, Brown R. Neonatal venlafaxine discontinuation syndrome: a mini-review. Eur J Paediatr Neurol 2017; 21(2): 264\u2013268, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27931774 (accessed 28 August 2019).","DOI":"10.1016\/j.ejpn.2016.11.003"},{"key":"bibr4-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Levinson-Castiel R, Merlob P, Linder N, et al. Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants. Arch Pediatr Adolesc Med 2006; 160(2): 173\u2013176, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16461873 (accessed 4 September 2019).","DOI":"10.1001\/archpedi.160.2.173"},{"key":"bibr5-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Rampono J, Simmer K, Ilett KF, et al. Placental transfer of SSRI and SNRI antidepressants and effects on the neonate. Pharmacopsychiatry 2009; 42(3): 95\u2013100, http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0028-1103296 (accessed 1 September 2019).","DOI":"10.1055\/s-0028-1103296"},{"key":"bibr6-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Hoppenbrouwers CJC, Bosma J, Wennink HJMB, et al. Neonatal seizures on EEG after in utero exposure to venlafaxine. Br J Clin Pharmacol 2010; 70(3): 454\u2013456, http:\/\/doi.wiley.com\/10.1111\/j.1365-2125.2010.03714.x (accessed 4 September 2019).","DOI":"10.1111\/j.1365-2125.2010.03714.x"},{"key":"bibr7-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Boucher N, Koren G, Beaulac-Baillargeon L. Maternal use of venlafaxine near term: correlation between neonatal effects and plasma concentrations. Ther Drug Monit 2009; 31(3): 404\u2013409, https:\/\/insights.ovid.com\/crossref?an=00007691-200906000-00015 (accessed 28 August 2019).","DOI":"10.1097\/FTD.0b013e3181a58fb4"},{"key":"bibr8-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Paulzen M, Schoretsanitis G, Gr\u00fcnder G, et al. Pregnancy exposure to venlafaxine\u2014therapeutic drug monitoring in maternal blood, amniotic fluid and umbilical cord blood and obstetrical outcomes. J Affect Disord 2020; 266: 578\u2013584, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32056930 (accessed 11 May 2020).","DOI":"10.1016\/j.jad.2020.02.010"},{"key":"bibr9-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Koren G, Moretti M, Kapur B. Can venlafaxine in breast milk attenuate the norepinephrine and serotonin reuptake neonatal withdrawal syndrome? J Obstet Gynaecol Can 2006; 28(4): 299\u2013301, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16776907 (accessed 28 August 2019).","DOI":"10.1016\/S1701-2163(16)32135-1"},{"key":"bibr10-2050313X20952981","doi-asserted-by":"crossref","unstructured":"Ilett KF, Hackett LP, Dusci LJ, et al. Distribution and excretion of venlafaxine and O-desmethylvenlafaxine in human milk. Br J Clin Pharmacol 1998; 45(5): 459\u2013462, http:\/\/doi.wiley.com\/10.1046\/j.1365-2125.1998.00710.x (accessed 28 August 2019).","DOI":"10.1046\/j.1365-2125.1998.00710.x"},{"key":"bibr11-2050313X20952981","unstructured":"de Moor RA, Mourad L, ter Haar J, et al. [Withdrawal symptoms in a neonate following exposure to venlafaxine during pregnancy]. Ned Tijdschr Geneeskd 2003; 147(28): 1370\u20131372, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12892015 (accessed 11 May 2020)."}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20952981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X20952981","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20952981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T10:42:13Z","timestamp":1740912133000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X20952981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":11,"alternative-id":["10.1177\/2050313X20952981"],"URL":"https:\/\/doi.org\/10.1177\/2050313x20952981","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2050313X20952981"}}