{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:37:40Z","timestamp":1770838660915,"version":"3.50.1"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> Pulmonary tumor thrombotic microangiopathy is a rare condition in which embolization of tumor cells to the pulmonary arterioles causes fibrocellular intimal thickening and activation of the coagulation cascade resulting in pulmonary hypertension and right heart failure. Herein, we highlight a young 35-year-old male with no known past medical history who presented with recurrent syncope and dyspnea, and was found to have severe right heart failure and pulmonary hypertension. He developed sudden clinical deterioration and died after a cardiac arrest. Autopsy revealed poorly differentiated gastric adenocarcinoma and pulmonary tumor thrombotic microangiopathy. New onset severe pulmonary hypertension and right heart failure without any other obvious etiology should encourage the reader to evaluate for pulmonary tumor thrombotic microangiopathy and undergo a diligent search for underlying malignancy. This case highlights recurrent syncope as a rare presentation of this rapidly fatal disease. <\/jats:p>","DOI":"10.1177\/2050313x20969044","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T03:54:49Z","timestamp":1603857289000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pulmonary tumor thrombotic microangiopathy presenting as recurrent syncope"],"prefix":"10.1177","volume":"8","author":[{"given":"Constanza","family":"Burciaga Calderoni","sequence":"first","affiliation":[{"name":"Department of Medicine and Pediatrics, Loma Linda University Health, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafne T","family":"Moretta","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Merrill-Henry","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care Services, Loma Linda University Medical Center, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0271-8572","authenticated-orcid":false,"given":"Paresh C","family":"Giri","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Loma Linda University, Loma Linda, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"bibr1-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<587::AID-CNCR2820660330>3.0.CO;2-J"},{"key":"bibr2-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1177\/2045894019851000"},{"key":"bibr3-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMimc1906466"},{"key":"bibr4-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000297"},{"key":"bibr5-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp298"},{"key":"bibr6-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306627"},{"key":"bibr7-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2015.07.525"},{"key":"bibr8-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.4103\/jpcs.jpcs_39_18"},{"key":"bibr9-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1177\/2045894019834890"},{"key":"bibr10-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1136\/thx.34.3.380"},{"key":"bibr11-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.4076\/1752-1947-3-7440"},{"key":"bibr12-2050313X20969044","first-page":"112","volume":"26","author":"Henderson S","year":"2018","journal-title":"Netherlands J Crit Care"},{"key":"bibr13-2050313X20969044","first-page":"1941293","volume":"2016","author":"Podda M","year":"2016","journal-title":"Case Rep Surg"},{"key":"bibr14-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1159\/000331664"},{"key":"bibr15-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01940-X"},{"key":"bibr16-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.045906"},{"key":"bibr17-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1467-7"},{"key":"bibr18-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.6.908"},{"key":"bibr19-2050313X20969044","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000071"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20969044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X20969044","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20969044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T09:50:26Z","timestamp":1740822626000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X20969044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":19,"alternative-id":["10.1177\/2050313X20969044"],"URL":"https:\/\/doi.org\/10.1177\/2050313x20969044","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2050313X20969044"}}