{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:19:40Z","timestamp":1782307180188,"version":"3.54.5"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> Hailey\u2013Hailey disease is a rare autosomal dominant acantholytic disorder due to mutation in the ATP2C1 gene and presents with flaccid blisters in intertriginous regions. Its chronic and relapsing course may negatively impact patients\u2019 quality of life. Multiple medical and interventional treatments have been described with various efficacy. Low-dose naltrexone and oral magnesium chloride represent emerging treatments. Sustained improvement in Hailey\u2013Hailey disease has been reported with the former in case series, while others have shown variable results. Oral magnesium chloride has been reported in four patients with possible results after 2\u20134\u2009weeks. Two recent cases suggest that the combination of both treatments may have a synergistic effect. Herein, we present a 63-year-old woman with long-standing and recurrent bilateral inguinal Hailey\u2013Hailey disease who significantly improved with low-dose naltrexone and oral magnesium chloride, representing the third case described with this combination. <\/jats:p>","DOI":"10.1177\/2050313x20984121","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T09:47:28Z","timestamp":1608889648000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Improvement in Hailey\u2013Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-8134","authenticated-orcid":false,"given":"Darosa","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Belisle","sequence":"additional","affiliation":[{"name":"Department of Pathology, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Davar","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,25]]},"reference":[{"key":"bibr1-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1939.01480220064005"},{"key":"bibr2-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1038\/71701"},{"key":"bibr3-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb00658.x"},{"key":"bibr4-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410025462"},{"key":"bibr5-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00477-z"},{"key":"bibr6-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2019.06.022"},{"key":"bibr7-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700031"},{"key":"bibr8-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1177\/1203475419843122"},{"key":"bibr9-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.2446"},{"key":"bibr10-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.12.031"},{"key":"bibr11-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.5463"},{"key":"bibr12-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.2445"},{"key":"bibr13-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18861"},{"key":"bibr14-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.024"},{"key":"bibr15-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12410"},{"key":"bibr16-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.198459"},{"key":"bibr17-2050313X20984121","doi-asserted-by":"publisher","DOI":"10.1177\/1203475418756377"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20984121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X20984121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X20984121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T18:21:40Z","timestamp":1740853300000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X20984121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":17,"alternative-id":["10.1177\/2050313X20984121"],"URL":"https:\/\/doi.org\/10.1177\/2050313x20984121","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"2050313X20984121"}}