{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:04:52Z","timestamp":1769720692033,"version":"3.49.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p> Ustekinumab is a biologic agent with Food and Drug Administration approval for the treatment of moderate-to-severe plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn\u2019s disease. It functions to inhibit the p40 subunit common to both interleukin-12 and interleukin-23. These pro-inflammatory cytokines are implicated in autoinflammatory and autoimmune disorders, but they also play an important role in cell-mediated immunity against viral, bacterial, and fungal pathogens. Therefore, antagonism of interleukin-12 and interleukin-23 by ustekinumab may increase the risk of human papillomavirus infection or reactivation which can lead to the development of verrucae. To the best of our knowledge, there is only one published report of disseminated verrucosis secondary to ustekinumab treatment for psoriasis. Here, we present the first case report of ustekinumab-induced disseminated verrucosis occurring in the setting of treatment for Crohn\u2019s disease. <\/jats:p>","DOI":"10.1177\/2050313x211003056","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T09:15:05Z","timestamp":1615972505000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A case report of disseminated verrucosis secondary to ustekinumab in a patient with Crohn\u2019s disease"],"prefix":"10.1177","volume":"9","author":[{"given":"Steven A","family":"Svoboda","sequence":"first","affiliation":[{"name":"School of Medicine, Virginia Tech Carilion, Roanoke, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick S","family":"Rush","sequence":"additional","affiliation":[{"name":"Section of Dermatology, School of Medicine, Virginia Tech Carilion, Roanoke, VA, USA"},{"name":"Department of Basic Science Education, School of Medicine, Virginia Tech Carilion, Roanoke, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin G","family":"Sharghi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L","family":"Rady","sequence":"additional","affiliation":[{"name":"Department of Dermatology, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen K","family":"Tyring","sequence":"additional","affiliation":[{"name":"Department of Dermatology, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D","family":"Eikenberg","sequence":"additional","affiliation":[{"name":"Section of Dermatology, School of Medicine, Virginia Tech Carilion, Roanoke, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"bibr1-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-019-00797-3"},{"key":"bibr2-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.07.016"},{"key":"bibr3-2050313X211003056","unstructured":"Stelara (Ustekinumab). Horsham, PA: Janssen Biotech, Inc. 2020."},{"key":"bibr4-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0765-6"},{"key":"bibr5-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2018.08.014"},{"key":"bibr6-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2004.08.007"},{"key":"bibr7-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(03)00109-5"},{"key":"bibr8-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0572-RA"},{"key":"bibr9-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.12.028"},{"key":"bibr10-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.279"},{"issue":"1","key":"bibr11-2050313X211003056","volume":"2","author":"Ko\u00e7 E","year":"2008","journal-title":"J Turk Acad Dermatol"},{"key":"bibr12-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4020260"},{"key":"bibr13-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.010017-0"},{"key":"bibr14-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i36.4093"},{"key":"bibr15-2050313X211003056","doi-asserted-by":"publisher","DOI":"10.3390\/v9100303"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X211003056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X211003056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X211003056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T16:20:22Z","timestamp":1741105222000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X211003056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":15,"alternative-id":["10.1177\/2050313X211003056"],"URL":"https:\/\/doi.org\/10.1177\/2050313x211003056","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"2050313X211003056"}}