{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:16:00Z","timestamp":1764494160280,"version":"3.41.2"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p> Merkel cell carcinoma (MCC) and malignant melanoma are aggressive skin cancers that usually arise in sun-exposed parts of the body. This report describes an 85-year-old man who underwent a wide local excision and sentinel lymph node biopsy for primary MCC and was subsequently found to have metastatic MCC and malignant melanoma within the left inguinal sentinel lymph node. Dual diagnoses of aggressive cutaneous carcinomas, although rare, may become more common in regions of high ultraviolet exposure and an ageing population. Currently, there are no guidelines for treating synchronous MCC and melanoma, however, immunotherapy with PD-1 inhibitors and anti-CTLA-4 receptor antagonists have shown therapeutic effect against these two cancers and should be considered in treatment planning. <\/jats:p>","DOI":"10.1177\/2050313x211023685","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T10:37:16Z","timestamp":1623839836000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Metastatic Merkel cell carcinoma and malignant melanoma in a single sentinel lymph node"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-5772","authenticated-orcid":false,"given":"Amanda","family":"Hamilton","sequence":"first","affiliation":[{"name":"Townsville University Hospital, Townsville, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasad","family":"Jayaratne","sequence":"additional","affiliation":[{"name":"Sullivan Nicolaides Pathology, Mater Hospital Pimlico, Townsville, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Zonta","sequence":"additional","affiliation":[{"name":"North Queensland Minimally Invasive Surgery, Mater Hospital Pimlico, Townsville, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"bibr1-2050313X211023685","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6494"},{"key":"bibr2-2050313X211023685","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0616"},{"key":"bibr3-2050313X211023685","unstructured":"DermNet NZ. Merkel cell carcinoma, 1996, http:\/\/www.dermnetnz.org\/topics\/merkel-cell-carcinoma\/ (accessed 1 June 2020)."},{"key":"bibr4-2050313X211023685","unstructured":"DermNet NZ. 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Merkel cell skin cancer, 2013, http:\/\/www.cancer.org (accessed 1 June 2020).","DOI":"10.1155\/2013\/929364"},{"key":"bibr13-2050313X211023685","doi-asserted-by":"crossref","unstructured":"American Cancer Society. Melanoma skin cancer, 2013, http:\/\/www.cancer.org (accessed 1 June 2020).","DOI":"10.1155\/2013\/735282"},{"key":"bibr14-2050313X211023685","unstructured":"Cancer Council Australia. Clinical practice guidelines for the diagnosis and management of melanoma, 2017, https:\/\/wiki.cancer.org.au\/australia\/Guidelines:Melanoma (accessed 1 June 2020)."},{"key":"bibr15-2050313X211023685","doi-asserted-by":"publisher","DOI":"10.4174\/astr.2018.95.5.286"},{"key":"bibr16-2050313X211023685","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10100350"},{"key":"bibr17-2050313X211023685","unstructured":"NSW Government eviQ, Cancer Institute NSW. Skin cancer Merkel cell carcinoma definitive EBRT, 2003, https:\/\/www.eviq.org.au\/radiation-oncology\/skin\/1142-skin-cancer-non-melanoma-merkel-cell-carcinom#references (accessed 1 June 2020)."},{"key":"bibr18-2050313X211023685","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.1168"},{"key":"bibr19-2050313X211023685","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0310-x"},{"key":"bibr20-2050313X211023685","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_200241"},{"key":"bibr21-2050313X211023685","unstructured":"ClinicalTrials.gov, NIH: U.S. National Library of Medicine. 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