{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:16:07Z","timestamp":1768317367851,"version":"3.49.0"},"reference-count":8,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Sinus histiocytosis with massive lymphadenopathy, also known as Rosai\u2013Dorfman disease, is a rare proliferation of non-Langerhans histiocytes. Cutaneous Rosai\u2013Dorfman disease is a rare subtype of Rosai\u2013Dorfman disease limited to the skin with variable clinical presentation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary:<\/jats:title><jats:p> A 59-year-old female with a history of osteoarthritis, hypothyroidism, and follicular B-cell lymphoma presented with pruritic, erythematous, dome-shaped papules that developed while on chemotherapy treatment. During cutaneous disease progression, the patient was further diagnosed with myelodysplastic syndrome. Histology review revealed patchy staining for S100 in the CD68+ histiocytes within the dermis with no enlarged histiocytes or emperipolesis. Given the absence of other findings, this was interpreted as cutaneous Rosai\u2013Dorfman disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> There is still little known about the aetiology and pathogenesis of cutaneous Rosai\u2013Dorfman disease. Non-specific immunohistochemistry in the midst of lymphoma, immunosuppressive treatments, and myelodysplastic syndrome produced a blurred diagnostic picture and delayed appropriate treatment, highlighting the diagnostic challenges of cutaneous Rosai\u2013Dorfman disease. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2050313x211046455","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T11:10:48Z","timestamp":1631790648000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Emergence of cutaneous Rosai\u2013Dorfman disease during immunosuppressive treatment of follicular B-cell lymphoma: A case report"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5910-9823","authenticated-orcid":false,"given":"Sharon L","family":"Kipfer","sequence":"first","affiliation":[{"name":"The University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Samycia","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science, The University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J","family":"Shiau","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science, The University of British Columbia, Vancouver, BC, Canada"},{"name":"Department of Pathology, Royal Columbian Hospital, New Westminster, BC, Canada"},{"name":"Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"issue":"1","key":"bibr1-2050313X211046455","first-page":"63","volume":"87","author":"Rosai J","year":"1969","journal-title":"Arch Pathol"},{"key":"bibr2-2050313X211046455","first-page":"171","volume":"103","author":"Gaul M","year":"2019","journal-title":"Cutis"},{"key":"bibr3-2050313X211046455","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2019.151446"},{"key":"bibr4-2050313X211046455","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2019.02.004"},{"key":"bibr5-2050313X211046455","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200210000-00001"},{"key":"bibr6-2050313X211046455","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164477"},{"key":"bibr7-2050313X211046455","unstructured":"Sewon K, Amagai M, Bruckner AL, et al. Fitzpatrick\u2019s dermatology. 9th ed. 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