{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:40:17Z","timestamp":1753882817711,"version":"3.41.2"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p> Multisystem inflammatory syndrome in children is an emerging pediatric illness associated with severe acute respiratory syndrome coronavirus 2 infection. The syndrome is rare, and evidence-based guidelines are lacking. This report reviews a patient who presented for medical care multiple times early in the course of his illness, thus offering near-daily documentation of symptoms and laboratory abnormalities. The patient did not have thrombocytopenia, anemia, or myocardial inflammation until the fifth day of fever. These laboratory abnormalities coincided with the onset of rash, conjunctival injection, vomiting, and diarrhea: clinical signs that could serve as indicators for when to obtain blood tests. The timing of this patient\u2019s onset of multisystem involvement suggests that testing for multisystem inflammatory syndrome in children after only 24 h of fever, as the Centers for Disease Control and Prevention recommends, may yield false-negative results. Testing for multisystem inflammatory syndrome in children after 4 days of fever may be more reliable. <\/jats:p>","DOI":"10.1177\/2050313x211050891","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T13:35:15Z","timestamp":1633700115000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Five days of fever and myocardial inflammation"],"prefix":"10.1177","volume":"9","author":[{"given":"Keli D","family":"Coleman","sequence":"first","affiliation":[{"name":"Section of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Benz","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5779-433X","authenticated-orcid":false,"given":"Nirzar S","family":"Parikh","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Health System, Marshfield, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny G","family":"Thomas","sequence":"additional","affiliation":[{"name":"Section of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Segar","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Block","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-0179","authenticated-orcid":false,"given":"Megan L","family":"Schultz","sequence":"additional","affiliation":[{"name":"Section of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"bibr1-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01263-3"},{"key":"bibr2-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1172\/JCI149633"},{"key":"bibr3-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"bibr4-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31094-1"},{"key":"bibr5-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006979"},{"key":"bibr6-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1002\/art.41616"},{"key":"bibr7-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202288"},{"key":"bibr8-2050313X211050891","unstructured":"Paediatric Intensive Care Society (PICS). 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Scientific brief: multisystem inflammatory syndrome in children and adolescents with COVID-19, https:\/\/www.who.int\/publications\/i\/item\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19 (accessed 17 October 2020)."},{"key":"bibr11-2050313X211050891","unstructured":"Health department-reported cases of multisystem inflammatory syndrome in children (MIS-C) in the United States, https:\/\/www.cdc.gov\/mis-c\/cases\/index.html (accessed 27 September 2021)."},{"key":"bibr12-2050313X211050891","unstructured":"Information for healthcare providers about multisystem inflammatory syndrome in children, https:\/\/www.cdc.gov\/mis-c\/hcp\/ (2020, accessed 28 September 2020)."},{"key":"bibr13-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"bibr14-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10369"},{"issue":"4","key":"bibr15-2050313X211050891","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1542\/peds.95.4.475","volume":"95","author":"Yanagawa H","year":"1995","journal-title":"Pediatrics"},{"key":"bibr16-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181cf8705"},{"key":"bibr17-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048360"},{"key":"bibr18-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141113"},{"key":"bibr19-2050313X211050891","unstructured":"Belay E, Cheung E, Oster M, et al. Clinical management of multisystem inflammatory syndrome in Children (MIS-C) associated with coronavirus disease 2019 (COVID-19), https:\/\/emergency.cdc.gov\/coca\/calls\/2020\/callinfo_071620.asp (accessed 8 October 2020)."},{"key":"bibr20-2050313X211050891","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.10.026"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X211050891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X211050891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X211050891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T18:33:08Z","timestamp":1741026788000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X211050891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":20,"alternative-id":["10.1177\/2050313X211050891"],"URL":"https:\/\/doi.org\/10.1177\/2050313x211050891","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"2050313X211050891"}}