{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:41:13Z","timestamp":1753882873967,"version":"3.41.2"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> We report on the case of a patient with dysgerminoma, a rare germ cell tumor, which showed hypercalcemia with an elevation of 1\u03b1,25-dihydroxycholecalciferol (calcitriol). A 27-year-old nulliparous woman presented with hypercalcemia during the examination of a right ovarian tumor with an elevation of calcitriol, lactate dehydrogenase, and alkaline phosphatase. Fractional excretion of calcium was elevated, and intact parathyroid hormone was suppressed. After undergoing right salpingo-oophorectomy, the patient\u2019s serum calcium and calcitriol returned to the normal range within a week. A literature search was conducted on the topic by reviewing databases for dysgerminoma showing hypercalcemia. We identified 14 patients from the literature and performed a pooled analysis, including the results of our case. However, most cases lack data that can help investigate the potential association between parathyroid hormone, parathyroid hormone-related protein, calcitriol, and phosphorus in hypercalcemia. Thus, more case reports that include additional information are required to fully elucidate the mechanism of hypercalcemia associated with dysgerminoma. <\/jats:p>","DOI":"10.1177\/2050313x211068562","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T10:34:12Z","timestamp":1642502052000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypercalcemia associated with dysgerminoma and elevation of calcitriol: A case report and review of the literature"],"prefix":"10.1177","volume":"10","author":[{"given":"Natsuko","family":"Hara","sequence":"first","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-630X","authenticated-orcid":false,"given":"Hirotsugu","family":"Suwanai","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyoshi","family":"Yakou","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munehiro","family":"Urayama","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumpei","family":"Shikuma","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Odawara","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Metabolism, Endocrinology, Rheumatology and Collagen Diseases, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"bibr1-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.63.743.745"},{"key":"bibr2-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199702000-00010"},{"key":"bibr3-2050313X211068562","first-page":"128","volume":"95","author":"Tewari K","year":"2000","journal-title":"Obstet Gynecol"},{"key":"bibr4-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000216004.22588.ce"},{"key":"bibr5-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.06.052"},{"key":"bibr6-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2018.05.004"},{"key":"bibr7-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31829bcaf1"},{"key":"bibr8-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.08.060"},{"key":"bibr9-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/956935"},{"key":"bibr10-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20476"},{"key":"bibr11-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63343-3"},{"key":"bibr12-2050313X211068562","first-page":"1302","volume":"108","author":"Radhakrishna S","year":"2001","journal-title":"BJOG"},{"key":"bibr13-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.24773"},{"key":"bibr14-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050327"},{"issue":"3","key":"bibr15-2050313X211068562","first-page":"113","volume":"25","author":"Inoue H","year":"1995","journal-title":"Jpn J Clin Oncol"},{"key":"bibr16-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1016"},{"key":"bibr17-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.3109\/00016349309013353"},{"key":"bibr18-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60927-6"},{"key":"bibr19-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp042806"},{"key":"bibr20-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2016.011155"},{"key":"bibr21-2050313X211068562","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32833b7c23"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X211068562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X211068562","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X211068562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:30:27Z","timestamp":1740893427000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X211068562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":21,"alternative-id":["10.1177\/2050313X211068562"],"URL":"https:\/\/doi.org\/10.1177\/2050313x211068562","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"2050313X211068562"}}