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The tumour was positive for vimentin and SS18-SSX, and the spindle cells were positive for bcl-2; in contrast, the epithelioid tumour cells were positive for pan-cytokeratin, epithelial membrane antigen and CD99. There was no INI-loss in tumour cells. Then, the presence of the SYT-SSX gene fusion was demonstrated by fluorescence in situ hybridization. In addition, androgen receptor gene somatic mutations were detected by next-generation sequencing. However, 6\u2009months postoperatively, the patient had neither developed a recurrence nor received adjuvant radiotherapy and chemotherapy. Accurate diagnosis depends on morphological and immunohistochemical examination and a proper molecular analysis, and novel technologies can detect a wide variety of genetic alterations. Although androgen receptor somatic mutations cannot provide addition treatment at present, surgical resection with a clean margin and follow-up is an appropriate approach. <\/jats:p>","DOI":"10.1177\/2050313x211068646","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T11:18:10Z","timestamp":1641640690000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of a 22-year-old man with primary synovial sarcoma of the parapharyngeal space with an <i>AR<\/i> somatic mutation: A case report and review of the literature"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-2382","authenticated-orcid":false,"given":"He","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pathology, Xi\u2019an Daxing Hospital, Xi\u2019an, 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