{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:20:04Z","timestamp":1776921604288,"version":"3.51.2"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> Hemophagocytic lymphohistiocytosis is a rare and almost universally fatal disease in adults. A 60-year-old female patient presented to our hospital with a 3-day history of weakness and anorexia. Physical examination revealed severe pallor without lymphadenopathy or hepatosplenomegaly. The initial blood test showed a hemoglobin level of 2.6\u2009g\/dL and a platelet count of 76\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. Later the patient experienced persistent high fever for 1\u2009week without any obvious infective symptoms. Biochemical examination revealed hyperferritinemia and low natural killer cell viability. The bone marrow morphology showed hemophagocytosis and infiltration with metastatic small-cell lung cancer. The patient was diagnosed as small-cell lung cancer-related hemophagocytic lymphohistiocytosis. Subsequently, she underwent chemotherapy with dexamethasone and etoposide. However, the patient succumbed within 2\u2009weeks of presentation due to rapidly progressive disease. In conclusion, we reported the first hemophagocytic lymphohistiocytosis case with small-cell lung cancer. It is critical to have early identification of hemophagocytic lymphohistiocytosis in patients with small-cell lung cancer. <\/jats:p>","DOI":"10.1177\/2050313x221088146","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T09:22:06Z","timestamp":1647940926000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Concurrence of hemophagocytic lymphohistiocytosis and small-cell lung cancer in bone marrow: A case report and literature review"],"prefix":"10.1177","volume":"10","author":[{"given":"Wenyan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology, First Hospital of Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8381-7547","authenticated-orcid":false,"given":"Zhenxing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, First Hospital of Tsinghua University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"bibr1-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-551622"},{"key":"bibr2-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30826"},{"key":"bibr3-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13954"},{"key":"bibr4-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1001-18"},{"key":"bibr5-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.5892-20"},{"key":"bibr6-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"bibr7-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0172"},{"key":"bibr8-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61048-X"},{"issue":"8","key":"bibr9-2050313X221088146","first-page":"997","volume":"100","author":"Lehmberg K","year":"2015","journal-title":"Haematologica"},{"key":"bibr10-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v3.i10.144"},{"key":"bibr11-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30084"},{"key":"bibr12-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.1177\/107327481402100410"},{"key":"bibr13-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19230"},{"key":"bibr14-2050313X221088146","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14144"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X221088146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X221088146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X221088146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T09:52:40Z","timestamp":1740822760000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X221088146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":14,"alternative-id":["10.1177\/2050313X221088146"],"URL":"https:\/\/doi.org\/10.1177\/2050313x221088146","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"2050313X221088146"}}