{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:55:28Z","timestamp":1776077728372,"version":"3.50.1"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> Liquid silicone is a relatively inexpensive injectable used for soft tissue augmentation. Injection of silicone is associated with a risk of delayed granuloma formation associated with elevated levels of tumour necrosis factor-\u03b1. We report a case of recalcitrant silicone granulomas following facial injections of silicone successfully treated with tumour necrosis factor-\u03b1 blockade. Our case, as well as previous reports, demonstrates the effectiveness of this therapy for the treatment of foreign body granulomas from due to silicone. <\/jats:p>","DOI":"10.1177\/2050313x221093444","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T11:00:39Z","timestamp":1652266839000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of recalcitrant silicone granuloma treated with adalimumab: A case report"],"prefix":"10.1177","volume":"10","author":[{"given":"Orli M","family":"Silverberg","sequence":"first","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-4983","authenticated-orcid":false,"given":"Benoit M","family":"Cyrenne","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Dermatology, Women\u2019s College Hospital, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Croitoru","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew K","family":"Sandre","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kucy","family":"Pon","sequence":"additional","affiliation":[{"name":"Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"bibr1-2050313X221093444","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.00020.x"},{"issue":"9","key":"bibr2-2050313X221093444","first-page":"894","volume":"5","author":"Desai AM","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"bibr3-2050313X221093444","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03260160056016"},{"key":"bibr4-2050313X221093444","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc052625"},{"key":"bibr5-2050313X221093444","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1964.01600060054010"},{"key":"bibr6-2050313X221093444","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.03.032"},{"key":"bibr7-2050313X221093444","doi-asserted-by":"publisher","DOI":"10.1080\/09546630310020470"},{"key":"bibr8-2050313X221093444","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2021.03.007"},{"key":"bibr9-2050313X221093444","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.1.13"},{"key":"bibr10-2050313X221093444","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002630"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X221093444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X221093444","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X221093444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T01:45:15Z","timestamp":1740879915000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X221093444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":10,"alternative-id":["10.1177\/2050313X221093444"],"URL":"https:\/\/doi.org\/10.1177\/2050313x221093444","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"2050313X221093444"}}