{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:03:12Z","timestamp":1780344192238,"version":"3.54.1"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NIH ITS CTSA","award":["KL2 TR001441"],"award-info":[{"award-number":["KL2 TR001441"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> Chronic, non-healing venous ulcers of the lower extremity are often limb-threatening conditions. Their management is characterized by a prolonged and frequently frustrating clinical course that represents an economic burden to both the patient and healthcare system. During the last two decades, thermal ablation of underlying incompetent venous systems has been extensively utilized to treat chronic venous insufficiency. Despite successful correction of venous hypertension, a substantial subgroup of patients remain affected by non-healing venous ulcers, thus posing a significant clinical challenge. In this case report, we detail quantitative and qualitative wound treatment course in a patient refractory to standard interventions, by treatment with a combination of cell-free amniotic fluid and dehydrated amniotic membrane following successful thermal ablation of refluxing veins. <\/jats:p>","DOI":"10.1177\/2050313x221100882","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T08:20:36Z","timestamp":1653121236000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Safety and efficacy of acellular human amniotic fluid and membrane in the treatment of non-healing wounds in a patient with chronic venous insufficiency"],"prefix":"10.1177","volume":"10","author":[{"given":"Frederick S","family":"Ditmars","sequence":"first","affiliation":[{"name":"Department of Surgery, Transplant Division, The University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A","family":"Lind","sequence":"additional","affiliation":[{"name":"Carmel Foot Specialists, Charlotte, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T Christopher","family":"Broderick","sequence":"additional","affiliation":[{"name":"Merakris Therapeutics, RTP Frontier, Research Triangle Park, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2909-1666","authenticated-orcid":false,"given":"W Samuel","family":"Fagg","sequence":"additional","affiliation":[{"name":"Department of Surgery, Transplant Division, The University of Texas Medical Branch, Galveston, TX, USA"},{"name":"Merakris Therapeutics, RTP Frontier, Research Triangle Park, NC, USA"},{"name":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"bibr1-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2004.05.015"},{"key":"bibr2-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg166"},{"key":"bibr3-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2004.09.027"},{"key":"bibr4-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2014.03.002"},{"key":"bibr5-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-0473-5_1"},{"key":"bibr6-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2019.12.075"},{"key":"bibr7-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830235"},{"key":"bibr8-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1136\/jech.45.3.184"},{"key":"bibr9-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.01.079"},{"key":"bibr10-2050313X221100882","doi-asserted-by":"crossref","DOI":"10.1016\/j.jvs.2014.04.049","volume":"60","author":"O\u2019Donnell TF","year":"2014","journal-title":"J Vasc Surg"},{"key":"bibr11-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111633"},{"issue":"6","key":"bibr12-2050313X221100882","first-page":"1","volume":"10","author":"Medical Advisory Secretariat","journal-title":"Ont Health Technol Assess Ser 2010"},{"key":"bibr13-2050313X221100882","volume":"46","author":"Meissner MH","year":"2007","journal-title":"J Vasc Surg"},{"key":"bibr14-2050313X221100882","volume":"46","author":"Meissner MH","year":"2007","journal-title":"J Vasc Surg"},{"key":"bibr15-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2014.09.002"},{"key":"bibr16-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2015.05.002"},{"key":"bibr17-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2017.02.001"},{"key":"bibr18-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.05.069"},{"key":"bibr19-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33141"},{"key":"bibr20-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0404"},{"key":"bibr21-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.07.003"},{"key":"bibr22-2050313X221100882","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103156"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X221100882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X221100882","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X221100882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T09:36:29Z","timestamp":1740908189000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X221100882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":22,"alternative-id":["10.1177\/2050313X221100882"],"URL":"https:\/\/doi.org\/10.1177\/2050313x221100882","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"2050313X221100882"}}