{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:41:24Z","timestamp":1753882884113,"version":"3.41.2"},"reference-count":16,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p> Factor X deficiency is one of the rarest coagulation disorders representing 10% of all rare bleeding diseases with a frequency of 1:1,000,000. A 39-year-old male patient with no previous medical conditions was admitted to the hospital with a left carpal ganglion for surgical excision. Routine preoperative laboratory examination revealed a high international normalized ratio of 5.4 IU (0.8\u20131.1) and a prothrombin time of 72.2\u2009s (10.9\u201313.6), with an isolated factor X level of less than 5%. Genetic testing for congenital factor X deficiency identified a homozygous mutation c.271\u2009&gt;\u2009A (p.Glu91). Vitamin K supplementation did not improve his international normalized ratio or increase factor X levels; hence, surgery was delayed. The patient was re-hospitalized to remove a wisdom tooth, during which fresh frozen plasma was administered. An allergic reaction complicated this procedure in the form of a rash on the body. As a result, the tooth was removed without active bleeding. This report presents a unique factor X deficiency case with limited treatment options to improve factor X levels after failed vitamin K administration and an allergic reaction to fresh frozen plasma. A physician\u2019s observation and ongoing follow-up were the only reasonable approaches in treating the patient with mild to moderate factor X deficiency due to lack of prothrombin complex concentrates or factor X replacement at the center at the time. <\/jats:p>","DOI":"10.1177\/2050313x221116676","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T12:13:05Z","timestamp":1659528785000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A case report of congenital factor X deficiency in an adult patient"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-5769","authenticated-orcid":false,"given":"Rehab Y","family":"AL-Ansari","sequence":"first","affiliation":[{"name":"Adult Hematology Unit, Internal Medicine Department, King Fahad Military Medical City (KFMMC), Dhahran, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghufran","family":"Alofi","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, King Fahad Military Medical City (KFMMC), Dhahran, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Aljarah","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, King Fahad Military Medical City (KFMMC), Dhahran, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Woodman","sequence":"additional","affiliation":[{"name":"Vice Deanship of Postgraduate Studies and Research, Prince Sultan Military College of Health Sciences, Dhahran, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"bibr1-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800276-6.00002-4"},{"key":"bibr2-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-46202-0.00004-2"},{"key":"bibr3-2050313X221116676","unstructured":"National Organization for Rare Disorders (NORD). Factor X Deficiency, 2018, https:\/\/rarediseases.org\/rare-diseases\/factor-x-deficiency"},{"key":"bibr4-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01856.x"},{"key":"bibr5-2050313X221116676","volume":"7","author":"Dejhansathit S","year":"2019","journal-title":"J Investig Med High Impact Case Rep"},{"key":"bibr6-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1055\/a-1496-8527"},{"key":"bibr7-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2018.05.002"},{"key":"bibr8-2050313X221116676","first-page":"1138329","volume":"2021","author":"Bangolo A","year":"2021","journal-title":"Case Rep Hematol"},{"key":"bibr9-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2014.01.007"},{"key":"bibr10-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.663"},{"key":"bibr11-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1225763"},{"key":"bibr12-2050313X221116676","unstructured":"National Institute of Health. Factor X deficiency, 2019, https:\/\/rarediseases.info.nih.gov\/diseases\/6404\/factor-x-deficiency"},{"key":"bibr13-2050313X221116676","unstructured":"National Library of Medicine. Factor X deficiency, 2015, http:\/\/ghr.nlm.nih.gov\/condition\/factor-x-deficiency"},{"key":"bibr14-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12893"},{"key":"bibr15-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13058"},{"key":"bibr16-2050313X221116676","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02635.x"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X221116676","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X221116676","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X221116676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T01:53:58Z","timestamp":1740880438000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X221116676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":16,"alternative-id":["10.1177\/2050313X221116676"],"URL":"https:\/\/doi.org\/10.1177\/2050313x221116676","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"type":"print","value":"2050-313X"},{"type":"electronic","value":"2050-313X"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"2050313X221116676"}}