{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T03:15:26Z","timestamp":1788146126505,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Reactive infectious mucocutaneous eruption is a recently distinguished mucosal-predominant blistering eruption triggered by respiratory infections. We describe a previously healthy 11-year-old Black female with rapidly progressive mucocutaneous blistering after prodromal respiratory infection symptoms. Reactive infectious mucocutaneous eruption was suspected and treated with systemic corticosteroids followed by etanercept. Twenty-four\u2009hours after etanercept, the diagnosis of multisystem inflammatory syndrome in children was raised and intravenous immunoglobulin was given. Rapidly worsening mucocutaneous disease ensued but was controlled by a second dose of etanercept. Our case highlights the following: (1) the novel observation of possible interaction\/neutralization of etanercept by intravenous immunoglobulin, (2) the challenging differential diagnosis of multisystem inflammatory syndrome in children for reactive infectious mucocutaneous eruption patients in the Coronavirus disease 2019 (COVID-19) pandemic, and (3) the role of early treatment to prevent dyspigmentation.<\/jats:p>","DOI":"10.1177\/2050313x221117887","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T03:03:17Z","timestamp":1660705397000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Reactive infectious mucocutaneous eruption \u2013 repeat etanercept after intravenous immunoglobulin: A case report"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5532-0250","authenticated-orcid":false,"given":"Rochelle","family":"Tonkin","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Ladha","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Toronto, Toronto, ON, Canada"},{"name":"Sunnybrook Health Sciences Centre, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Johnson","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F","family":"Astle","sequence":"additional","affiliation":[{"name":"Pediatric Ophthalmology, Vision Clinic, Alberta Children\u2019s Hospital, Department of Surgery, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Britton","sequence":"additional","affiliation":[{"name":"Wound Care\/Surgery Clinic Nurse, Department of Pediatrics, Alberta Children\u2019s Hospital, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil H","family":"Shear","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Toronto, Toronto, ON, Canada"},{"name":"Sunnybrook Health Sciences Centre, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Murgu\u00eda-Favela","sequence":"additional","affiliation":[{"name":"Section of Hematology and Immunology, Department of Pediatrics, Alberta Children\u2019s Hospital, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Ramien","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Division of Community Pediatrics (Dermatology), Department of Pediatrics, Alberta Children\u2019s Hospital, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"bibr1-2050313X221117887","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.06.026"},{"key":"bibr2-2050313X221117887","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20063"},{"key":"bibr3-2050313X221117887","doi-asserted-by":"publisher","DOI":"10.1177\/1203475419874444"},{"key":"bibr4-2050313X221117887","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13778"},{"key":"bibr5-2050313X221117887","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.5166"},{"key":"bibr6-2050313X221117887","unstructured":"Alberta Health Services. 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