{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:40:24Z","timestamp":1753882824062,"version":"3.41.2"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> A 71-year-old non-smoker woman was admitted to our hospital because of left front chest pain. A computed tomography scan showed a large mass of &gt;7.0\u2009cm in the lower left part of the lung and multiple organ metastases in the liver, brain, bone, and left adrenal gland. Pathological analysis of a resected specimen obtained by bronchoscopy revealed keratinization. In addition, p40 was positive and thyroid transcription factor-1, synaptophysin, CD56, and chromogranin A were negative by immunohistochemistry. Programmed cell death ligand 1 expression was 1%\u201310%, and exon 19 deletion was detected. We diagnosed the patient with stage IVB lung squamous cell carcinoma and administered osimertinib. Osimertinib was later replaced with afatinib because of grade 3 skin rash. Overall, the size of the cancer was decreased. Furthermore, her symptoms, laboratory data, and computer tomographic findings markedly improved. In summary, we experienced a case of epidermal growth factor receptor\u2013positive lung squamous cell carcinoma that was responsive to epidermal growth factor receptor tyrosine kinase inhibitors. <\/jats:p>","DOI":"10.1177\/2050313x231159504","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T10:57:10Z","timestamp":1678013830000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of epidermal growth factor receptor tyrosine kinase inhibitor effectiveness in epidermal growth factor receptor mutation-positive squamous cell carcinoma"],"prefix":"10.1177","volume":"11","author":[{"given":"Sosuke","family":"Matsumura","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, University of Tsukuba, Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-1868","authenticated-orcid":false,"given":"Satoshi","family":"Ano","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University of Tsukuba, Tsukuba, Japan"},{"name":"Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Tsuchiura, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Tsuchiura, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Tsuchiura, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Kasumigaura Medical Center, Tsuchiura, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzuru","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, National Hospital Organization Kasumigaura Medical Center, Tsuchiura, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Ibarakihigashi National Hospital, Tokai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Hizawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University of Tsukuba, Tsukuba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"bibr1-2050313X231159504","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31827690b5"},{"key":"bibr2-2050313X231159504","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01887.x"},{"key":"bibr3-2050313X231159504","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-019-01431-z"},{"key":"bibr4-2050313X231159504","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2370"},{"key":"bibr5-2050313X231159504","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt205"},{"key":"bibr6-2050313X231159504","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-016-2133-4"},{"key":"bibr7-2050313X231159504","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8745"},{"key":"bibr8-2050313X231159504","unstructured":"U.S. Department of Health & Human Services. 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