{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:22:18Z","timestamp":1776730938088,"version":"3.51.2"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["SAGE Open Medical Case Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p> Alopecia areata is a non-scarring, autoimmune hair loss disorder that is associated with inflammatory bowel disease. Alopecia areata and inflammatory bowel disease may have a common pathogenic mechanism that involves the Janus kinase\/STAT pathway. In addition, there are previous case reports of patients who developed alopecia areata while on biologic therapies for inflammatory bowel disease. JAK1 inhibitors are currently undergoing investigation as potential therapies for Crohn\u2019s disease. Upadacitinib, an oral JAK1 inhibitor, has demonstrated efficacy in treating Crohn\u2019s disease during phase III clinical trials. In this case report, we present a 23-year-old man with Crohn\u2019s disease who previously developed alopecia areata while on adalimumab. He had near-complete resolution of his alopecia universalis after 7\u2009months of treatment with upadacitinib while on concurrent ustekinumab for Crohn\u2019s disease, which he had been taking for 16\u2009months prior to starting upadacitinib. Upadacitinib may be a beneficial therapy for treating concomitant alopecia areata and Crohn\u2019s disease. <\/jats:p>","DOI":"10.1177\/2050313x231160914","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T09:37:23Z","timestamp":1679391443000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Successful treatment of concomitant alopecia universalis and Crohn\u2019s disease with upadacitinib: A case report"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0994-1603","authenticated-orcid":false,"given":"Leah A","family":"Johnston","sequence":"first","affiliation":[{"name":"Health Sciences Centre, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Lu","sequence":"additional","affiliation":[{"name":"Health Sciences Centre, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M","family":"Poelman","sequence":"additional","affiliation":[{"name":"Health Sciences Centre, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Beacon Dermatology, Calgary, AB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"bibr1-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8620-9"},{"key":"bibr2-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.955035"},{"key":"bibr3-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2020.1702878"},{"key":"bibr4-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.104157"},{"key":"bibr5-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10235660"},{"key":"bibr6-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz186"},{"key":"bibr7-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2019.03.002"},{"key":"bibr8-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1159\/000512747"},{"key":"bibr9-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15346"},{"key":"bibr10-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16316"},{"key":"bibr11-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000780"},{"key":"bibr12-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0273-0"},{"key":"bibr13-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153084"},{"key":"bibr14-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1159\/000113945"},{"issue":"11","key":"bibr15-2050313X231160914","doi-asserted-by":"crossref","first-page":"13030","DOI":"10.5070\/D32111029286","volume":"21","author":"Toda-Brito H","year":"2015","journal-title":"Dermatol Online J"},{"key":"bibr16-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12057"},{"key":"bibr17-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2010.1041"},{"issue":"7","key":"bibr18-2050313X231160914","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5070\/D34G31C0TM","volume":"18","author":"Verros C","year":"2012","journal-title":"Dermatol Online J"},{"key":"bibr19-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2017.07.009"},{"key":"bibr20-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13699"},{"key":"bibr21-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14816"},{"key":"bibr22-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000690"},{"key":"bibr23-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.10.027"},{"key":"bibr24-2050313X231160914","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16342"}],"container-title":["SAGE Open Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X231160914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2050313X231160914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2050313X231160914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:31:17Z","timestamp":1740789077000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2050313X231160914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":24,"alternative-id":["10.1177\/2050313X231160914"],"URL":"https:\/\/doi.org\/10.1177\/2050313x231160914","relation":{},"ISSN":["2050-313X","2050-313X"],"issn-type":[{"value":"2050-313X","type":"print"},{"value":"2050-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"2050313X231160914"}}